Trial reportJournal of perinatology : official journal of the California Perinatal Association2019
Does ultrasound guidance for peripherally inserted central catheter (PICC) insertion reduce the incidence of tip malposition? - a randomized trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- [Clinical practice guideline for point-of-care ultrasound-guided peripherally inserted central catheter placement in neonates (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Guideline
- Devices for Neonatal Peripheral Catheterization and Tip Confirmation: A Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- Pooled it
- Systematic review of ultrasound-guided central venous catheter placement-related complications in neonates and infants aged <12 months.The Journal of international medical research · 2024Pooled it
- Prevention of complications related to peripherally inserted central catheter insertion techniques in newborns: systematic review and network meta-analysis.Revista latino-americana de enfermagem · 2024Pooled it
- Effect of video-assisted education on informed consent and patient education for peripherally inserted central catheters: a randomized controlled trial.The Journal of international medical research · 2020Trial
- Article
- The Role of Bedside Ultrasonography in Neonatal Central Venous Access Applications.Sisli Etfal Hastanesi tip bulteni · 2026Review
- Umbilical venous catheter and peripherally inserted central catheter malposition and tip migration in neonates: A mixed methods cost analysis.International journal of nursing studies advances · 2025Article
- Comparison of Catheter Malposition Incidence in Peripherally Inserted Central Catheters Between Left and Right Upper Limbs: A Cross-Sectional Study.Health science reports · 2025Article
- Clinical validation of the diagnosis adverse location of peripherally inserted central catheter in neonatology.Revista da Escola de Enfermagem da U S P · 2025Article
- Correcting Peripherally Inserted Central Catheter Placement by External Manipulation of the Upper Limb Extremity.Cureus · 2024Article
- Usefulness of skills in point of care ultrasound and simulation-based training as essential competencies in acute management of neonatal cardiac tamponade.BMJ case reports · 2024Article
- Case Report: A report on the countermeasures after PICC line breakage in 3 postoperative breast cancer patients.Frontiers in surgery · 2024Article
- The Role of Ultrasound in Epicutaneo-Caval Catheter Insertion in Neonates: Systematic Review, Meta-Analysis and Future Perspectives.Diagnostics (Basel, Switzerland) · 2023Review
- Observational
- A modified method for measuring the length of peripherally inserted central catheters to reduce the risk of malposition during catheter insertion.SAGE open medicine · 2023Article
- The relationship between the PICC tip position and weight gain, length growth of premature infants under ultrasonography: a correlation analysis study.Frontiers in medicine · 2023Article
- Agitated saline contrast to delineate central venous catheter position in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- [Operation and management guidelines for peripherally inserted central catheter in neonates (2021)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the study was to evaluate the incidence of peripheral inserted central catheter (PICC) tip malposition when the catheter is inserted under real-time ultrasound (RTUS) guidance when compared with conventional landmark (CL) technique in neonates. Additional objectives were to evaluate the PICC longevity and central line associated blood stream infections (CLABSI). STUDY
designIn this randomised controlled trial, neonates were randomised to 'RTUS' (n = 40) or 'CL' (n = 40) groups. PICC tip was placed under ultrasound guidance in lower third of superior vena cava in the RTUS group. In 'CL' group, PICC was inserted as calculated by anatomical landmarks.
resultsThe birth weight (1286 (926, 1662) vs. 1061 (889, 1636) g) and gestation (31.12 (3.1) vs. 31.4 (3.6) wks) were comparable among the groups. RTUS guidance during PICC insertion reduced incidence of tip malposition by 52% (67.5 vs. 32.5%; RR: 0.48; 95% CI: 0.29-0.79). The longevity of PICC and episodes of CLABSI were however similar in the two groups.
conclusionsReal-time ultrasound guidance during PICC placement reduces the incidence of tip malposition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.