ArticleNature communications2018
Imaging neural activity in the ventral nerve cord of behaving adult Drosophila.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
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- Centralized brain networks controlling antennal grooming coordination.Nature communications · 2026Article
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- Specialized parallel pathways for adaptive control of visual object pursuit.bioRxiv : the preprint server for biology · 2025Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
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- Presynaptic inhibition selectively suppresses leg proprioception in behavingbioRxiv : the preprint server for biology · 2024Article
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- Descending control of motor sequences in Drosophila.Current opinion in neurobiology · 2024Review
- A leg model based on anatomical landmarks to study 3D joint kinematics of walking inFrontiers in bioengineering and biotechnology · 2024Article
- Fine-grained descending control of steering in walkingbioRxiv : the preprint server for biology · 2023Article
- Article
- Olfactory navigation in arthropods.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila.Nature neuroscience · 2023Article
- Ascending neurons convey behavioral state to integrative sensory and action selection brain regions.Nature neuroscience · 2023Article
- The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility.Genetics · 2023Article
- Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors.eLife · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
To understand neural circuits that control limbs, one must measure their activity during behavior. Until now this goal has been challenging, because limb premotor and motor circuits have been largely inaccessible for large-scale recordings in intact, moving animals-a constraint that is true for both vertebrate and invertebrate models. Here, we introduce a method for 2-photon functional imaging from the ventral nerve cord (VNC) of behaving adult Drosophila melanogaster. We use this method to reveal patterns of activity across nerve cord populations during grooming and walking and to uncover the functional encoding of moonwalker ascending neurons (MANs), moonwalker descending neurons (MDNs), and a previously uncharacterized class of locomotion-associated A1 descending neurons. Finally, we develop a genetic reagent to destroy the indirect flight muscles and to facilitate experimental access to the VNC. Taken together, these approaches enable the direct investigation of circuits associated with complex limb movements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.