ArticleEmerging microbes & infections2018
Identification and genetic characterization of a novel parvovirus associated with serum hepatitis in horses in China.
Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Molecular prevalence of equine parvovirus hepatitis in healthy horses from the Northern region of the state of Rio Grande do Sul, Brazil.Veterinary research communications · 2026Article
- Article
- Detection of Equine Parvovirus-Hepatitis Virus and Equine Hepacivirus in Archived Sera from Horses in France and Australia.Viruses · 2024Article
- Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses.Veterinary pathology · 2024Article
- Identification and Genome Characterization of a Novel Muscovy Duck-Origin Goose Parvovirus with Three Recombinant Regions between Muscovy Duck Parvovirus and Goose Parvovirus.Transboundary and emerging diseases · 2024Article
- Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks.Virology journal · 2022Article
- Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022Article
- Active equine parvovirus-hepatitis infection is most frequently detected in Austrian horses of advanced age.Equine veterinary journal · 2022Article
- Genetic characterization of three recently discovered parvoviruses circulating in equines in China.Frontiers in veterinary science · 2022Article
- Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea.Veterinary sciences · 2021Article
- First Detection and Genetic Characterization of New Equine Parvovirus Species Circulating among Horses in Korea.Veterinary sciences · 2021Article
- Investigation of Three Newly Identified Equine Parvoviruses in Blood and Nasal Fluid Samples of Clinically Healthy Horses and Horses with Acute Onset of Respiratory Disease.Animals : an open access journal from MDPI · 2021Article
- Article
- Equine parvovirus hepatitis.Equine veterinary journal · 2021Review
- Equine Parvovirus-Hepatitis Screening in Horses and Donkeys with Histopathologic Liver Abnormalities.Viruses · 2021Article
- Clinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis.Viruses · 2021Article
- First report of equine parvovirus-hepatitis-associated Theiler's disease in Europe.Equine veterinary journal · 2020Article
- The First Nonmammalian Pegivirus Demonstrates EfficientJournal of virology · 2020Article
- Tropism, pathology, and transmission of equine parvovirus-hepatitis.Emerging microbes & infections · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel equine parvovirus, equine parvovirus-hepatitis (EqPV-H), was first discovered in a horse that died of equine serum hepatitis in the USA in 2018. EqPV-H was shown to be a novel etiological agent associated with equine serum hepatitis. Following this initial report, no additional studies on EqPV-H have been published. In this study, a total of 143 serum samples were collected from racehorses at 5 separate farms in China and were analyzed to detect EqPV-H DNA via nested PCR. The results indicated a high prevalence of EqPV-H (11.9%, 17/143) in the studied animals. In addition, a remarkably high coinfection rate (58.8%, 10/17) with 2 equine flaviviruses (equine hepacivirus and equine pegivirus) was observed in the EqPV-H positive equines. However, all equines tested negative for Theiler's disease-associated virus, an etiological agent associated with equine serum hepatitis. The genomes of six field EqPV-H strains were sequenced and analyzed, with the results indicating that the Chinese EqPV-H strains have low genetic diversity and high genetic similarity with the USA EqPV-H strain BCT-01. A phylogenetic analysis demonstrated that the Chinese EqPV-H strains clustered with BCT-01 in the genus Copiparvovirus but were distantly related to another equine parvovirus identified in horse cerebrospinal fluid. In addition, liver enzyme levels were detected in the EqPV-H positive serum samples, and all the values were in the normal range, indicating that infection can occur without concurrent liver disease. This study will promote an understanding of the geographical distribution, genetic diversity, and pathogenicity of EqPV-H.
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