Evidence map›Paper›PMID 30348899›Full record

ArticleThe Journal of biological chemistry2018

Two clusters of residues contribute to the activity and substrate specificity of Fm1, a bifunctional oleate and linoleate desaturase of fungal origin.

Yuanheng Cai, Xiao-Hong Yu, Qun Liu, Chang-Jun Liu, John Shanklin

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Structure and Function of Alkane Monooxygenase (AlkB).Accounts of chemical research · 2023
    Review
  2. Article
  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanheng CaiFrom the Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, New York 11794 and.
Xiao-Hong YuFrom the Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, New York 11794 and.
Qun LiuBiology Department, Brookhaven National Laboratory, Upton, New York 11973.
Chang-Jun LiuBiology Department, Brookhaven National Laboratory, Upton, New York 11973.
John ShanklinFrom the Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, New York 11794 and shanklin@bnl.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) have important industrial, physiological, and nutritional properties. Plants use the sequential activities of FAD2 and FAD3 desaturases to convert 18:1Δ9 to the important PUFA 18:3Δ9,12,15, whereas the fungus

Indexed as

Amino Acid SequenceCatalytic DomainFatty Acid DesaturasesFusariumLinoleic AcidModels, MolecularMutagenesis, Site-DirectedMutationOleic AcidSubstrate SpecificityFatty Acid DesaturasesLinoleic AcidOleic Acidbifunctional desaturasedehydrogenasefatty acid metabolismFm1lipid metabolismphospholipidpolyunsaturated fatty acidregioselectivitystructural determinantsstructure-functionsubstrate specificityΔ12 and ω3 desaturases

Identifiers

PMID30348899
PMCPMC6314118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.