Evidence map›Paper›PMID 30348894›Full record

ArticleMolecular pharmacology2019

Macroscopic and Microscopic Activation of

Marta Quadri, Sumanta Garai, Ganesh A Thakur, Clare Stokes, Alican Gulsevin, Nicole A Horenstein, Roger L Papke

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Therapeutic Targeting ofPharmacological reviews · 2021
    Review
  10. Article
  11. Article
  12. Allosterically PotentiatedMolecular pharmacology · 2020
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Heteromeric Neuronal Nicotinic Acetylcholine Receptors with MutantThe Journal of pharmacology and experimental therapeutics · 2019
    Article
  19. Allosteric Agonism ofMolecular pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marta QuadriDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Sumanta GaraiDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Ganesh A ThakurDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Clare StokesDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Alican GulsevinDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Nicole A HorensteinDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.).
Roger L PapkeDepartments of Pharmacology and Therapeutics (M.Q., C.S., R.L.P.) and Chemistry (M.Q., A.G., N.A.H.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.) rlpapke@ufl.edu.
University of Florida · USNortheastern University · US

Funding

Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY024717NIGMS NIH HHS R01 GM057481
6 · The paper itself

Abstract

B-973 is an efficacious type II positive allosteric modulator (PAM) of

Indexed as

Allosteric RegulationAllosteric Sitealpha7 Nicotinic Acetylcholine ReceptorAnimalsFemaleHumansMecamylamineMembrane ProteinsNicotinic AgonistsPhenylpropionatesPiperazinesProtein DomainsQuinolinesSulfonamidesXenopus laevis4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinoline-8-sulfonamidealpha7 Nicotinic Acetylcholine ReceptorB-973 compoundMecamylamineMembrane ProteinsNicotinic AgonistsPhenylpropionatesPiperazinesQuinolinesSulfonamides

Identifiers

PMID30348894
PMCPMC6277926
OpenAlexW2896613243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.