ArticleThe EMBO journal2018
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.
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Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
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Who cites it
65 citing papers in PubMed, 126 citations in OpenAlex.
- The Crosstalk Between YAP/TAZ and Cancer Metabolism: From Mechanistic Insights to Drug Discovery.International journal of molecular sciences · 2026Review
- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- Targeting YAP: mechanistic breakthroughs and therapeutic prospects in reversing organ fibrosis.Molecular and cellular biochemistry · 2026Review
- Cellular mechanometabolism: stimuli and implications.EMBO reports · 2026Review
- Stretch strain shifts optic nerve head astrocyte metabolism to enrich α-ketoglutarate and the pentose phosphate pathway.Scientific reports · 2026Article
- Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Nononcology Drugs.Cancer research · 2026Article
- In vivo screen reveals specific roles of Hippo pathway components in development and regeneration.Life science alliance · 2026Article
- Article
- Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling.bioRxiv : the preprint server for biology · 2025Article
- Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection.Journal of medical virology · 2025Review
- YAP/TAZ Promote GLUT1 Expression and Are Associated with Prognosis in Endometrial Cancer.Cancers · 2025Article
- SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting Hippo-YAP/TAZ signaling pathway: an updated review demonstrating the therapeutic potential of key plant derived anticancer compounds.Frontiers in pharmacology · 2025Review
- Cell signaling inFrontiers in cellular and infection microbiology · 2025Review
- Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids.Nature communications · 2024Article
- Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway.Scientific reports · 2024Article
- Article
- CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer.Science advances · 2024Article
- A two-way street - cellular metabolism and myofibroblast contraction.NPJ Regenerative medicine · 2024Review
- The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.The Journal of clinical investigation · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 8 institutions in 1 country.
Andrew G CoxBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA andrew.cox@petermac.org wolfram_goessling@hms.harvard.edu.ORCID 0000-0003-4189-9422
Allison TsomidesBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dean YimlamaiBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Katie L HwangBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joel MiesfeldMedical College of Wisconsin, Milwaukee, WI, USA.
Giorgio G GalliBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Brendan H FowlBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michael FortBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3314-6706
Kimberly Y MaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mark R SullivanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aaron M HosiosKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Erin SnayBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Min YuanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kristin K BrownBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Evan C LienKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sagar ChhangawalaWeill Cornell Medical College and New York Presbyterian Hospital, New York, NY, USA.
Matthew L SteinhauserBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John M AsaraBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Yariv HouvrasWeill Cornell Medical College and New York Presbyterian Hospital, New York, NY, USA.
Brian LinkMedical College of Wisconsin, Milwaukee, WI, USA.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-6702-4192
Fernando D CamargoBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5630-5909
Wolfram GoesslingBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA andrew.cox@petermac.org wolfram_goessling@hms.harvard.edu.ORCID 0000-0001-9972-1569
Boston Children's Hospital · USBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBroad Institute · USMassachusetts Institute of Technology · USMedical College of Wisconsin · USNewYork–Presbyterian Hospital · USHarvard University · US
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MPRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MSTRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MA Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3MEstrogen Regulation of Hepatic GrowthR01DK090311 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2011 to 2020
$4.9MMetabolic Regulation of Liver GrowthR01DK105198 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2016 to 2020
$2.7MHippo Signaling Mediates the Development of Liver FibrosisK08DK105351 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YIMLAMAI, DEAN · 2015 to 2019
$796kNCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NIDDK NIH HHS K08 DK105351NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK090311NIDDK NIH HHS R01 DK105198NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32 GM007753NIH HHS R24 OD017870
Abstract
The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity have been identified, little is known about the Yap target genes that mediate these growth effects. Here, we show that
Indexed as
AnimalsGlucoseGlucose Transporter Type 1Hippo KinasesLiverMiceNucleotidesProtein Serine-Threonine KinasesSerine-Threonine Kinase 3Signal TransductionTrans-ActivatorsYAP-Signaling ProteinsZebrafishZebrafish ProteinsGlucoseGlucose Transporter Type 1Hippo KinasesNucleotidesProtein Serine-Threonine KinasesSerine-Threonine Kinase 3stk3 protein, zebrafishTrans-ActivatorsYAP-Signaling ProteinsYes-associated protein (yap), zebrafishZebrafish Proteinsglucose metabolismglut1Hippo pathwayliver developmentYap
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.