Evidence map›Paper›PMID 30348801›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Forces drive basement membrane invasion in

Rodrigo Cáceres, Nagagireesh Bojanala, Laura C Kelley, Jes Dreier, John Manzi, Fahima Di Federico, Qiuyi Chi, Thomas Risler, Ilaria Testa, David R Sherwood and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  3. Article
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  5. Imaging actin organisation and dynamics in 3D.Journal of cell science · 2024
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  8. Article
  9. Review
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  12. Article
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  14. Review
  15. The extracellular matrix in development.Development (Cambridge, England) · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodrigo CáceresLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France.
Nagagireesh BojanalaLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France.
Laura C KelleyDepartment of Biology, Regeneration Next, Duke University, Durham, NC 27705.
Jes DreierDepartment of Applied Physics and Science for Life Laboratory, KTH Royal Institute of Technology, 10014 Stockholm, Sweden.ORCID 0000-0002-9596-5125
John ManziLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France.
Fahima Di FedericoLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France.
Qiuyi ChiDepartment of Biology, Regeneration Next, Duke University, Durham, NC 27705.
Thomas RislerLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France.ORCID 0000-0003-1677-4636
Ilaria TestaDepartment of Applied Physics and Science for Life Laboratory, KTH Royal Institute of Technology, 10014 Stockholm, Sweden.
David R SherwoodDepartment of Biology, Regeneration Next, Duke University, Durham, NC 27705.
Julie PlastinoLaboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS, 75005 Paris, France; julie.plastino@curie.fr.

Funding

Understanding how cells invade through basement membrane in vivoR35GM118049 · NIGMS · DUKE UNIVERSITY · PI David R Sherwood · 2016 to 2026
$6.8M
Genetic Analysis of Cell Invasion through Basement MembranesR01GM079320 · NIGMS · DUKE UNIVERSITY · PI SHERWOOD, DAVID R · 2007 to 2015
$2.8M
Visualizing and Elucidating the Role of Force on Type IV Collagen in DevelopmentR21HD084290 · NICHD · DUKE UNIVERSITY · PI SHERWOOD, DAVID R · 2016 to 2017
$412k
NICHD NIH HHS R21 HD084290NIGMS NIH HHS R01 GM079320NIGMS NIH HHS R35 GM118049
6 · The paper itself

Abstract

During invasion, cells breach basement membrane (BM) barriers with actin-rich protrusions. It remains unclear, however, whether actin polymerization applies pushing forces to help break through BM, or whether actin filaments play a passive role as scaffolding for targeting invasive machinery. Here, using the developmental event of anchor cell (AC) invasion in

Indexed as

Gene Expression Regulation, DevelopmentalMechanotransduction, CellularActin-Related Protein 2-3 ComplexActinsAnimalsBasement MembraneBiomechanical PhenomenaCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MovementEukaryotic CellsFetal ProteinsForminsGenes, ReporterGreen Fluorescent ProteinsLamininActin-Related Protein 2-3 ComplexActinsCaenorhabditis elegans ProteinsFetal ProteinsForminsGreen Fluorescent ProteinsLamininLuminescent ProteinsMicrofilament ProteinsNuclear ProteinsRed Fluorescent Proteinwsp-1 protein, C eleganswve-1 protein, C elegansactin cytoskeletonanchor cellArp2/3 complexcell invasionforce production

Identifiers

PMID30348801
PMCPMC6233148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.