Evidence map›Paper›PMID 30348782›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut.

Reed Pifer, Regan M Russell, Aman Kumar, Meredith M Curtis, Vanessa Sperandio

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  10. Review
  11. DadY (PA5303) is required for fitness ofMicrobial cell (Graz, Austria) · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Long Chain Fatty Acids and Virulence Repression in Intestinal Bacterial Pathogens.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Reed PiferDepartment of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390.
Regan M RussellDepartment of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390.
Aman KumarDepartment of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390.
Meredith M CurtisDepartment of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390.
Vanessa SperandioDepartment of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390; vanessa.sperandio@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USSouthwestern Medical CenterSouthwestern Medical Center · US

Funding

MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
AI-3 Inhibitors as treatment for bacterial infectionsU01AI077853 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2008 to 2012
$6.5M
Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
SdiA regulation of EHEC virulenceR01AI077613 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2009 to 2017
$3.4M
Tryptophan derivatives in EHEC pathogenesisR01AI114511 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2015 to 2019
$2.3M
Sugar Regulation of EHEC virulence - A1R56AI105135 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARESSO, ANTHONY W, SPERANDIO, VANESSA · 2018 to 2018
$499k
Branched Chain Amino Acid Metabolism During AnthraxR21AI146481 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2020
$440k
NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI077613NIAID NIH HHS R01 AI114511NIAID NIH HHS R21 AI146481NIAID NIH HHS R37 AI053067NIAID NIH HHS R56 AI105135NIAID NIH HHS T32 AI007520NIAID NIH HHS U01 AI077853
6 · The paper itself

Abstract

The gut metabolic landscape is complex and is influenced by the microbiota, host physiology, and enteric pathogens. Pathogens have to exquisitely monitor the biogeography of the gastrointestinal tract to find a suitable niche for colonization. To dissect the important metabolic pathways that influence virulence of enterohemorrhagic

Indexed as

Amino AcidsEscherichia coliFatty AcidsIntestinesOxidation-ReductionVirulenceAmino AcidsFatty AcidscutREHECenterohemorrhagic E. colifadL

Identifiers

PMID30348782
PMCPMC6233112
OpenAlexW2898076487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.