Evidence map›Paper›PMID 30348684›Full record

ArticleIn vivo (Athens, Greece)

Virome Analysis Reveals No Association of Head and Neck Vascular Anomalies with an Active Viral Infection.

Nora Franke, Michael Bette, André Marquardt, Thomas Briese, W Ian Lipkin, Christopher Kurz, Jovine Ehrenreich, Elisabeth Mack, Bianka Baying, Vladimir Beneš and 8 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Nora FrankeDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Michael BetteInstitute of Anatomy and Cell Biology, Philipps University, Marburg, Germany.
André MarquardtDepartment of Hematology, Oncology and Immunology, University Hospital Giessen and Marburg, Marburg, Germany.
Thomas BrieseCenter for Infection and Immunity, Columbia University, New York City, NY, U.S.A.
W Ian LipkinCenter for Infection and Immunity, Columbia University, New York City, NY, U.S.A.
Christopher KurzDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Jovine EhrenreichDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Elisabeth MackDepartment of Hematology, Oncology and Immunology, University Hospital Giessen and Marburg, Marburg, Germany.
Bianka BayingGenomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
Vladimir BenešGenomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
Fiona R RodepeterInstitute of Pathology, Philipps University, Marburg, Germany.
Andreas NeffDepartment of Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Afshin TeymoortashDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Behfar EivaziDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Urban GeisthoffDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Boris A StuckDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany.
Udo BakowskyDepartment of Pharmaceutical Technology and Biopharmacy, Philipps University, Marburg, Germany.
Robert MandicDepartment of Otolaryngology/Head and Neck Surgery, University Hospital Giessen and Marburg, Marburg, Germany mandic@med.uni-marburg.de.
Universitätsklinikum Gießen und Marburg · DEPhilipps University of Marburg · DEEuropean Molecular Biology Laboratory · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimVascular anomalies encompass different vascular malformations [arteriovenous (AVM), lymphatic (LM), venous lymphatic (VLM), venous (VM)] and vascular tumors such as hemangiomas (HA). The pathogenesis of vascular anomalies is still poorly understood. Viral infection was speculated as a possible underlying cause. MATERIALS AND

methodsA total of 13 human vascular anomalies and three human skin control tissues were used for viral analysis. RNA derived from AVM (n=4) and normal skin control (n=3) tissues was evaluated by RNA sequencing. The Virome Capture Sequencing Platform for Vertebrate Viruses (VirCapSeq-VERT) was deployed on 10 tissues with vascular anomalies (2×AVM, 1×HA, 1×LM, 2×VLM, 4×VM).

resultsRNA sequencing did not show any correlation of AVM with viral infection. By deploying VirCapSeq-VERT, no consistent viral association was seen in the tested tissues.

conclusionThe analysis does not point to the presence of an active viral infection in vascular anomalies. However, transient earlier viral infections, e.g. during pregnancy, cannot be excluded with this approach.

Indexed as

Gene Expression Regulation, ViralHigh-Throughput Nucleotide SequencingHumansRNA, ViralVascular MalformationsVirus DiseasesVirusesRNA, Viralhead and neckvascular anomalyVirome

Identifiers

PMID30348684
PMCPMC6365735
OpenAlexW2896457232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.