Evidence map›Paper›PMID 30348640›Full record

ArticleJournal of lipid research2018

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency.

Takuya Takeichi, Yusuke Okuno, Akane Kawamoto, Takeshi Inoue, Eiko Nagamoto, Chiaki Murase, Eri Shimizu, Kenichi Tanaka, Yuichi Kageshita, Satoshi Fukushima and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Human genetic defects of sphingolipid synthesis.Journal of inherited metabolic disease · 2025
    Review
  4. Season- and facial site-specific skin changes due to long-term mask wearing during the COVID-19 pandemic.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022
    Article
  5. Microcephaly in Neurometabolic Diseases.Children (Basel, Switzerland) · 2022
    Review
  6. The efficacy of synthetic pseudo-ceramide for dry and rough lips.International journal of cosmetic science · 2021
    Article
  7. L-serine synthesis via the phosphorylated pathway in humans.Cellular and molecular life sciences : CMLS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Takuya TakeichiDepartment of Dermatology Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan takeichi@med.nagoya-u.ac.jp makiyama@med.nagoya-u.ac.jp.
Yusuke OkunoCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya 466-8550, Japan.
Akane KawamotoBiological Science Research Laboratories Kao Corporation, Haga, Tochigi 321-3497, Japan.
Takeshi InoueDepartment of Pediatrics Kumamoto University, Kumamoto 860-8556, Japan.
Eiko NagamotoDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Chiaki MuraseDepartment of Dermatology Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Eri ShimizuAnalytical Science Research Laboratories, Kao Corporation, Haga, Tochigi 321-3497, Japan.
Kenichi TanakaDepartment of Pediatrics Kumamoto University, Kumamoto 860-8556, Japan.
Yuichi KageshitaDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Satoshi FukushimaDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Michihiro KonoDepartment of Dermatology Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Junko IshikawaBiological Science Research Laboratories Kao Corporation, Haga, Tochigi 321-3497, Japan.
Hironobu IhnDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Masashi AkiyamaDepartment of Dermatology Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan takeichi@med.nagoya-u.ac.jp makiyama@med.nagoya-u.ac.jp.
Kumamoto University · JPNagoya University · JPKao Corporation (Japan) · JPNagoya University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis:

Indexed as

Abnormalities, MultipleAdultAmino AcidsBrain DiseasesCarbohydrate Metabolism, Inborn ErrorsCeramidesExome SequencingFemaleFetal Growth RetardationGestational AgeHumansIchthyosisImmunohistochemistryInfant, NewbornLimb Deformities, CongenitalMaleAmino AcidsCeramidesPhosphoglycerate DehydrogenaseSphingolipidsceramideskin barrier • ichthyosis • L-serine • sphingolipid

Identifiers

PMID30348640
PMCPMC6277160
OpenAlexW2896866693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.