Evidence map›Paper›PMID 30348620›Full record

ReviewEBioMedicine2018

Surgery, neuroinflammation and cognitive impairment.

Azeem Alam, Zac Hana, Zhaosheng Jin, Ka Chun Suen, Daqing Ma

4 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 273 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
273citing papers in PubMed, 10 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03963063 nacompletednot on this mapstarted 2019, after this paper: background citation

Efficacy of Perioperative Goal-directed Fluid Therapy in Preventing Cerebral Desaturation and Postoperative Cognitive Dysfunction After Beach Chair Position Shoulder Surgery

TypeinterventionalSponsorNational Taiwan University HospitalRan2019 to 2021Enrolled70ConditionsPostoperative Cognitive Dysfunction, AnesthesiaArmsGoal-directed fluid therapy, Non goal-directed fluid therapy
NCT04598178 completednot on this mapstarted 2020, after this paper: background citation

Normative Data for the Quick Mild Cognitive Impairment-Taiwan Version (Qmci- TQ) in a Taiwanese Sample

TypeobservationalSponsorNational Taiwan University HospitalRan2020 to 2021Enrolled30ConditionsPostoperative Cognitive Dysfunction
NCT04701801 completednot on this mapstarted 2020, after this paper: background citation

Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients

Typeobservational_patient_registrySponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalRan2020 to 2021Enrolled200ConditionsPostoperative Cognitive Dysfunction, Preoperative AnxietyArmsMoCA test
NCT05474872 unknown statusnot on this mapstarted 2022, after this paper: background citation

Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery

TypeobservationalSponsorInstitutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian FodorRan2022 to 2026Enrolled100ConditionsPostoperative Delirium, Cognitive ImpairmentArmsBIS monitoring
3 · Its place in the literature

Who cites it

273 citing papers in PubMed, 10 syntheses or guidelines pooled it, 426 citations in OpenAlex.

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  10. Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis.Advances in experimental medicine and biology · 2023
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213 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Azeem AlamAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Zac HanaAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Zhaosheng JinAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Ka Chun SuenAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Daqing MaAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. Electronic address: d.ma@imperial.ac.uk.
Imperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trauma experienced during surgery can contribute to the development of a systemic inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis. Various pro-inflammatory cytokines, such as TNFα, maintain a state of chronic neuroinflammation, manifesting as post-operative cognitive dysfunction and post-operative delirium. Furthermore, elderly patients with post-operative cognitive dysfunction or delirium are three times more likely to experience permanent cognitive impairment or dementia. We conducted a narrative review, considering evidence extracted from various databases including Pubmed, MEDLINE and EMBASE, as well as journals and book reference lists. We found that further pre-clinical and well-powered clinical studies are required to delineate the precise pathogenesis of post-operative delirium and cognitive dysfunction. Despite the burden of post-operative neurological sequelae, clinical studies investigating therapeutic agents, such as dexmedetomidine, ibuprofen and statins, have yielded conflicting results. In addition, evidence supporting novel therapeutic avenues, such as nicotinic and HMGB-1 targeting and remote ischaemic pre-conditioning, is limited and necessitates further investigation.

Indexed as

Brain Injuries, TraumaticCognitive DysfunctionDementiaInflammationPostoperative ComplicationsAnimalsDexmedetomidineHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIbuprofenDexmedetomidineHydroxymethylglutaryl-CoA Reductase InhibitorsIbuprofenInflammationMultiple organ dysfunction syndromeNeuroinflammationSurgerySystemic inflammatory response syndromeTherapeutic targets

Identifiers

PMID30348620
PMCPMC6284418
OpenAlexW2896540078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.