Evidence map›Paper›PMID 30348463›Full record

GuidelineClinical nutrition (Edinburgh, Scotland)2019

ESPEN guideline on clinical nutrition in the intensive care unit.

Pierre Singer, Annika Reintam Blaser, Mette M Berger, Waleed Alhazzani, Philip C Calder, Michael P Casaer, Michael Hiesmayr, Konstantin Mayer, Juan Carlos Montejo, Claude Pichard and 5 more

13 registry-linked trialsAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Clinical nutrition (Edinburgh, Scotland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 13 registered trials, which are not on this map. Cited by 1,043 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,043citing papers in PubMed, 21 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04177446 naunknown statusnot on this map

A Multicenter Randomized Controlled Clinical Study With WeiYuan Tai (a Nutritional Supplement) on Nutritional Support of Enhanced Protein in Severe Patients(Tai Shan)

TypeinterventionalSponsorPeking Union Medical College HospitalRan2019 to 2020Enrolled180ConditionsCritical IllnessArmsa production consist of various oligopeptides and the whey protein, basic energy intake, maltodextrin
NCT04303650 completednot on this mapstarted 2020, after this paper: background citation

The Relation Between Sonographic Quadriceps Muscle Layer Thickness and Nitrogen Balance for Nutrition Monitoring in Adult Critically Ill Trauma Patients

Typeobservational_patient_registrySponsorZagazig UniversityRan2020 to 2023Enrolled186ConditionsTraumaArmsUltrasound measurement of quadriceps muscle layer thickness
NCT04443335 nacompletednot on this mapstarted 2020, after this paper: background citation

Comparison of Continuous Feeding and Sequential Feeding on Gut Microbiota and Metabolomics in Critically Ill Patients

TypeinterventionalSponsorQingdao UniversityRan2020 to 2022Enrolled158ConditionsFeeding BehaviorArmscontinous feeding, sequential feeding
NCT04662242 phase4completednot on this mapstarted 2020, after this paper: background citation

The Prognostic Impact of Selenium On Critical Surgical Patients

TypeinterventionalSponsorChang Gung Memorial HospitalRan2020 to 2022Enrolled36ConditionsCritical Illness, Selenium Deficiency, Trace Element Deficiency, Acute AbdomenArmsSelenium Supplement, normal saline
NCT04841174 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Abdominal Massage on Gastric Problems in Patients With Enteral Nutrition in Pediatric Intensive Care: A Randomized Controlled Study

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2021 to 2023Enrolled24ConditionsIntensive Care Units, Pediatric, Massage, Nutrition Disorders, Nurse's RoleArmsAbdominal massage
NCT05710315 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Single-center, Proof of Concept, Prospective Study Evaluating the Utility of RELiZORB™ for the Treatment of Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure

TypeinterventionalSponsorInova Health Care ServicesRan2025 to 2026Enrolled32ConditionsMulti Organ Failure, Exocrine Pancreatic InsufficiencyArmsRELiZORB™, Placebo
NCT05879263 naunknown statusnot on this mapstarted 2022, after this paper: background citation

"Efficacy of Intermittent Enteral Nutrition Versus Continuous Administration in Intensive Care Patients for the Reduction of Complications. Randomized Clinical Trial"

TypeinterventionalSponsorComplejo Hospitalario Universitario de AlbaceteRan2022 to 2024Enrolled190ConditionsEnteral Nutrition, Critical Care, Feeding Methods, Gastric Feeding TubeArmsINTERMITTENT ENTERAL NUTRITITION (IEN), CONTINUOS ENTERAL NUTRITITION (CEN)
NCT05998902 phase3completednot on this mapstarted 2023, after this paper: background citation

Trophic Enteral Feeding Combined With Supplemental Parenteral Nutrition Treatment in Patients With Severe Stroke (OPENS-2): a Multicentre, Prospective, Randomised, Open-label, Blinded-endpoint Trial

TypeinterventionalSponsorWen Jiang-3Ran2023 to 2026Enrolled546ConditionsSevere Stroke, Acute Stroke, DysphagiaArmsTrophic enteral feeding combined with supplemental parenteral nutrition, Full enteral feeding
NCT06316986 nacompletednot on this mapstarted 2024, after this paper: background citation

Performance of the NGPOD® Device in Verifying the Correct Position in the Stomach of the Naso- or Oro- Gastric Tube in Intensive Care : Prospective Monocentric Clinical Investigation

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2024 to 2025Enrolled50ConditionsIntensive Care, NutritionArmspH indication with NGPOD
NCT06330610 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation de l'efficacité du Support Nutritionnel entéral Intermittent Sur la défaillance d'Organes de Patients de réanimation Sous Ventilation assistée ENteral NUTrition - Continue Intermittent

TypeinterventionalSponsorUniversity Hospital, RouenRan2024 to 2027Enrolled174ConditionsIntermittent Fasting, Septic Shock, Organ Failure, MultipleArmsIntermittent enteral nutrition
NCT07024264 completednot on this mapstarted 2022, after this paper: background citation

Caloric Estimation Using Predictive Equations and Indirect Calorimetry in ICU Patients

TypeobservationalSponsorTaipei Medical University Shuang Ho HospitalRan2022 to 2024Enrolled133ConditionsCritical Illness, Energy Requirement, Equation, Indirect CalorimetryArmsTotal energy requirement calculated by predictive equation
NCT07098611 recruitingnot on this mapstarted 2025, after this paper: background citation

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)

Typeobservational_patient_registrySponsorMedipol UniversityRan2025 to 2026Enrolled470ConditionsVentilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
NCT07620106 completednot on this mapstarted 2024, after this paper: background citation

Nutrition Day: Prevalenza Della Nutrizione Artificiale Nei Pazienti Ospedalizzati e Appropriatezza Prescrittiva a Supporto Della Valutazione Dei Costi e Della Programmazione Dei Consumi.

TypeobservationalSponsorUniversity of BariRan2024 to 2024Enrolled578ConditionsMalnourished Patients Requiring Artificial Nutritional Support
3 · Its place in the literature

Who cites it

1,043 citing papers in PubMed, 21 syntheses or guidelines pooled it.

  1. Guideline
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  5. The effect of blended tube feeding compared to conventional formula on clinical outcomes in adults: A systematic review.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2026
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  19. Guideline
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983 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Pierre SingerDepartment of General Intensive Care and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: psinger@clalit.org.il.
Annika Reintam BlaserDepartment of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia; Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland.
Mette M BergerService of Adult Intensive Care and Burns, Lausanne University Hospital, Lausanne, Switzerland.
Waleed AlhazzaniDepartment of Medicine, Division of Critical Care and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada.
Philip C CalderHuman Development and Health Academic Unit, Faculty of Medicine, University of Southampton and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Michael P CasaerClinical Department and Laboratory of Intensive Care Medicine, Catholic University Hospitals (UZLeuven) and Catholic University Leuven, Leuven, Belgium.
Michael HiesmayrDivision Cardiac-, Thoracic-, Vascular Anaesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.
Konstantin MayerUniversitätsklinikum Gießen Medizinische, Gießen, Germany.
Juan Carlos MontejoServicio de Medecina Intensiva, Hospital Universitario 12 de Octobre, Madrid, Spain.
Claude PichardClinical Nutrition, Geneva University Hospital, Geneva, Switzerland.
Jean-Charles PreiserDepartment of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Arthur R H van ZantenDepartment of Intensive Care, Gelderse Vallei Hospital, Ede, the Netherlands.
Simon OczkowskiDepartment of Medicine, Division of Critical Care and Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada.
Wojciech SzczeklikDepartment of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krakow, Poland.
Stephan C BischoffDepartment of Nutritional Medicine/Prevention, University of Hohenheim, Stuttgart, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the new ESPEN Standard Operating Procedures, the previous guidelines to provide best medical nutritional therapy to critically ill patients have been updated. These guidelines define who are the patients at risk, how to assess nutritional status of an ICU patient, how to define the amount of energy to provide, the route to choose and how to adapt according to various clinical conditions. When to start and how to progress in the administration of adequate provision of nutrients is also described. The best determination of amount and nature of carbohydrates, fat and protein are suggested. Special attention is given to glutamine and omega-3 fatty acids. Particular conditions frequently observed in intensive care such as patients with dysphagia, frail patients, multiple trauma patients, abdominal surgery, sepsis, and obesity are discussed to guide the practitioner toward the best evidence based therapy. Monitoring of this nutritional therapy is discussed in a separate document.

Indexed as

Nutritional StatusCritical CareCritical IllnessEnteral NutritionEuropeHumansIntensive Care UnitsNutritional SupportParenteral NutritionSocieties, MedicalEnteralESPENGuidelinesIntensive careNutritionParenteral

Identifiers

PMID30348463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 7 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.