Evidence map›Paper›PMID 30348221›Full record

Observational studyPediatric rheumatology online journal2018

Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis.

Kristin M Houghton, Heather M Macdonald, Heather A McKay, Jaime Guzman, Ciarán Duffy, Lori Tucker, LEAP Study Investigators

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric rheumatology online journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  12. Article
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  14. Review
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  16. Advances in Juvenile Spondyloarthritis.Current rheumatology reports · 2021
    Review
  17. Longitudinal changes in muscle power compared to muscle strength and mass.Journal of musculoskeletal & neuronal interactions · 2021
    Article
  18. Review
  19. [Fractures and bone mineral density in childhood].Zeitschrift fur Rheumatologie · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kristin M HoughtonDivision of Rheumatology, K4-123 ACB, British Columbia Children's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada. khoughton@cw.bc.ca.ORCID http://orcid.org/0000-0001-7174-1007
Heather M MacdonaldDepartment of Family Practice, University of British Columbia, Vancouver, BC, Canada.
Heather A McKayDepartment of Family Practice, University of British Columbia, Vancouver, BC, Canada.
Jaime GuzmanDivision of Rheumatology, K4-123 ACB, British Columbia Children's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Ciarán DuffyDivision of Rheumatology, Department of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Canada.
Lori TuckerDivision of Rheumatology, K4-123 ACB, British Columbia Children's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
LEAP Study Investigators
University of British Columbia · CAVancouver Coastal Health · CA

Funding

Canadian Institutes of Health Research 107535
6 · The paper itself

Abstract

backgroundArthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with juvenile idiopathic arthritis (JIA) but the exercise prescription to best promote bone and muscle health is unknown. We therefore aimed to: 1. assess feasibility and safety of a 6-month home- and group-based exercise program for children with JIA; 2. estimate the effect of program participation on bone mass and strength, muscle function and clinical outcomes and 3. determine if any positive changes in bone and muscle outcomes are maintained 6 months later.

methodsWe recruited 24 children with JIA who were part of the Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis (LEAP) study to participate in a 6-month home-based exercise program involving jumping and handgrip exercises, resistance training and one group exercise session per month. We assessed lumbar spine bone mass (dual energy X-ray absorptiometry), distal tibia and radius bone microarchitecture and strength (high-resolution peripheral quantitative computed tomography), muscle function (jumping mechanography, dynamometry) and clinical outcomes (joint assessment, function, health-related quality of life) at baseline, 6- and 12-months. Adherence was assessed using weekly activity logs.

resultsThirteen children completed the 6-month intervention. Participants reported 9 adverse events and post-exercise pain was rare (0.4%). Fatigue improved, but there were no other sustained improvements in muscle, bone or clinical outcomes. Adherence to the exercise program was low (47%) and decreased over time.

conclusionChildren with JIA safely participated in a home-based exercise program designed to enhance muscle and bone strength. Fatigue improved, which may in turn facilitate physical activity participation. Prescribed exercise posed adherence challenges and efforts are needed to address facilitators and barriers to participation in and adherence to exercise programs among children with JIA.

trial registrationData of the children with JIA are from the LEAP study (Canadian Institutes of Health Research (CIHR; GRANT# 107535 ). http://www.leapjia.com/.

Indexed as

Absorptiometry, PhotonAdolescentArthritis, JuvenileBone DensityCanadaChildCohort StudiesExercise TherapyFeasibility StudiesFemaleHumansLongitudinal StudiesMaleMuscle StrengthPatient ComplianceQuality of LifeBoneExerciseJuvenile arthritisMusclePhysical activity

Identifiers

PMID30348221
PMCPMC6198360
OpenAlexW2896626157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.