ArticleBreast cancer research : BCR2018
Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours.
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Radiation chronotherapy-clinical impact of treatment time-of-day: a systematic review.Journal of neuro-oncology · 2019Pooled it
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery.Iranian journal of basic medical sciences · 2026Review
- Circadian clock and cancer.Military Medical Research · 2026Review
- LILRB4 regulates circadian disruption-induced mammary tumorigenesis via non-canonical WNT signaling pathway.Oncogene · 2025Article
- Shaking culture attenuates circadian rhythms in induced pluripotent stem cells during osteogenic differentiation through the TEAD-Fbxl3-CRY axis.Cell death discovery · 2025Article
- Mechanical signatures in cancer metastasis.npj biological physics and mechanics · 2025Review
- The interplay between the PI3K/AKT pathway and circadian clock in physiologic and cancer-related pathologic conditions.Cell proliferation · 2024Review
- Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD.The Journal of cell biology · 2023Article
- Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis.Cancer cell international · 2023Article
- Role of Melatonin in Cancer: Effect on Clock Genes.International journal of molecular sciences · 2023Review
- Major roles of the circadian clock in cancer.Cancer biology & medicine · 2023Review
- BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion.Molecular biology reports · 2022Article
- Synergies of Multiple Zeitgebers Tune Entrainment.Frontiers in network physiology · 2021Article
- The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation.Cellular and molecular gastroenterology and hepatology · 2021Article
- Metabolic rivalry: circadian homeostasis and tumorigenesis.Nature reviews. Cancer · 2020Review
- Angiogenesis in Tissue Engineering: As Nature Intended?Frontiers in bioengineering and biotechnology · 2020Review
- Tumor suppressor role of genes involved in circadian clock control.EXCLI journal · 2019Article
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11 authors at 1 institution in 1 country.
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Abstract
backgroundCircadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptions have been proposed as a contributing factor for cancer initiation and progression, although definitive evidence for altered molecular circadian clocks in cancer is still lacking. In this study, we looked at circadian clocks in breast cancer.
methodsWe isolated primary tumours and normal tissues from the same individuals who had developed breast cancer with no metastases. We assessed circadian clocks within primary cells of the patients by lentiviral expression of circadian reporters, and the levels of clock genes in tissues by qPCR. We histologically examined collagen organisation within the normal and tumour tissue areas, and probed the stiffness of the stroma adjacent to normal and tumour epithelium using atomic force microscopy.
resultsEpithelial ducts were disorganised within the tumour areas. Circadian clocks were altered in cultured tumour cells. Tumour regions were surrounded by stroma with an altered collagen organisation and increased stiffness. Levels of Bmal1 messenger RNA (mRNA) were significantly altered in the tumours in comparison to normal epithelia.
conclusionCircadian rhythms are suppressed in breast tumour epithelia in comparison to the normal epithelia in paired patient samples. This correlates with increased tissue stiffness around the tumour region. We suggest possible involvement of altered circadian clocks in the development and progression of breast cancer.
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