Evidence map›Paper›PMID 30348201›Full record

ArticleBMC research notes2018

High report of miscarriage among women living with HIV who want to conceive in Uganda.

Sarah Finocchario-Kessler, Kathy Goggin, Vince Staggs, Rhoda K Wanyenze, Jolly Beyeza-Kashesya, Deborah Mindry, Josephine Birungi, Glenn J Wagner

Abstract read
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah Finocchario-KesslerDepartment of Family Medicine, University of Kansas Medical Center, Kansas City, USA. Skessler2@kumc.edu.
Kathy GogginHealth Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, USA.
Vince StaggsHealth Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, USA.
Rhoda K WanyenzeDepartment of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda.
Jolly Beyeza-KashesyaMulago Hospital Department of Obstetrics and Gynaecology, Makerere University College of Health Sciences, Kampala, Uganda.
Deborah MindryLos Angeles Center for Culture and Health, University of California, Los Angeles, USA.
Josephine BirungiThe AIDS Support Organization, Kampala, Uganda.
Glenn J WagnerRAND Corporation, Santa Monica, USA.

Funding

Determinants of Use of Safer Conception Strategies Among HIV Clients in UgandaR01HD072633 · NICHD · RAND CORPORATION · PI WAGNER, GLENN JOHN · 2012 to 2015
$1.3M
National Institute of Child Health and Human Development 5R01HD072633-04NICHD NIH HHS R01 HD072633
6 · The paper itself

Abstract

objectiveData on early miscarriage incidence is limited due to various social and methodological barriers. We report on 24-month pregnancy outcomes of 299 female Ugandan HIV clients in committed relationships with an intention to conceive. Miscarriage data are reported as auxiliary findings to a larger study (5R01HD072633).

results127 (42%) participants reported a pregnancy during the study; among the remaining 172, 82 indicated they stopped trying to conceive, and 16 dropped out prior to month 24. Of the 127 pregnancies, 55 (43%) resulted in live births, 67 (53%) in spontaneous miscarriage, 1 (< 1%) in stillbirth, 1 (< 1%) in abortion, and 3 (2%) in unknown outcomes. Three-quarters (75%) of miscarriages for which time until miscarriage was available were reported to occur in the first trimester (mean = 11.3 weeks gestation). The 67 participants who reported a miscarriage tended to be older (mean 33 vs. 30 years), but the significance of age did not persist after adjusting for multiple tests. We observed relatively low rates of pregnancy and high rates of miscarriage among this cohort of HIV-positive women wanting to conceive. Rigorously designed studies are needed to better understand the observed high rate of early miscarriage among HIV-infected women.

Indexed as

Pregnancy RateAbortion, SpontaneousAdolescentAdultFemaleHIV InfectionsHumansLive BirthMiddle AgedPregnancyStillbirthUgandaYoung AdultEarly miscarriageHIVMiscarriagePregnancy outcomesSerodiscordantUganda

Identifiers

PMID30348201
PMCPMC6198531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.