Evidence map›Paper›PMID 30348157›Full record

ArticleMalaria journal2018

Household costs and time to treatment for children with severe febrile illness in rural Burkina Faso: the role of rectal artesunate.

Joëlle Castellani, Borislava Mihaylova, Mohamadou Siribié, Zakaria Gansane, Amidou Z Ouedraogo, Florence Fouque, Sodiomon B Sirima, Silvia M A A Evers, Aggie T G Paulus, Melba Gomes

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Joëlle CastellaniDepartment of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands. j.castellani@alumni.maastrichtuniversity.nl.
Borislava MihaylovaHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Mohamadou SiribiéGroupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso.
Zakaria GansaneGroupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso.
Amidou Z OuedraogoGroupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso.
Florence FouqueUNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.
Sodiomon B SirimaGroupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso.
Silvia M A A EversDepartment of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Aggie T G PaulusDepartment of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Melba GomesUNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.
Groupe de Recherche et d’Action sur le Foncier · BFMaastricht University · NLWorld Health Organization · CHUniversity of Oxford · GB

Funding

European Commission PP-AP/2010/253-959UNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR) A80553World Health Organization 001
6 · The paper itself

Abstract

backgroundCommunity health workers (CHWs) were trained to identify children with malaria who could not take oral medication, treat them with rectal artesunate (RA) and refer them to the closest healthcare facility to complete management. However, many children with such symptoms did not seek CHWs' care. The hypothesis was that the cost of referral to a health facility was a deterrent. The goal of this study was to compare the out-of-pocket costs and time to seek treatment for children who sought CHW care (and received RA) versus those who did not.

methodsChildren with symptoms of severe malaria receiving RA at CHWs and children with comparable disease symptoms who did not go to a CHW were identified and their parents were interviewed. Household out-of-pocket costs per illness episode and speed of treatment were evaluated and compared between RA-treated children vs. non-RA treated children and by central nervous symptoms (CNS: repeated convulsions, altered consciousness or coma).

resultsAmong children with CNS symptoms, costs of RA-treated children were similar to those of non-RA treated children ($5.83 vs. $4.65; p = 0.52), despite higher transport costs ($2.74 vs. $0.91; p < 0.0001). However, among children without CNS symptoms, costs of RA-treated children were higher than the costs of non-RA treated children with similar symptoms ($5.62 vs. $2.59; p = 0.0001), and the main driver of the cost difference was transport. After illness onset, CNS children reached CHWs for RA an average of 9.0 h vs. 16.1 h for non-RA treated children reaching first treatment [difference 7.1 h (95% CI - 1.8 to 16.1), p = 0.11]. For non-CNS patients the average time to CHW-delivered RA treatment was 12.2 h vs. 20.1 h for those reaching first treatment [difference 7.9 h (95% CI 0.2-15.6), p = 0.04]. More non-RA treated children developed CNS symptoms before arrival at the health centre but the difference was not statistically significant (6% vs. 4%; p = 0.58).

conclusionsCommunity health worker-delivered RA does not affect the total out-of-pocket costs when used in children with CNS symptoms, but is associated with higher total out-of-pocket costs when used in children with less severe symptoms. RA-treated children sought treatment more quickly.

Indexed as

Time-to-TreatmentAdministration, RectalAntimalarialsArtesunateBurkina FasoChild, PreschoolCommunicable Disease ControlCommunity Health WorkersFamily CharacteristicsFemaleFeverHealth ExpendituresHumansInfantMaleRural PopulationAntimalarialsArtesunateCHWCosts and cost analysisEconomicsMalariaRDTsRectal artesunateTime to treatment

Identifiers

PMID30348157
PMCPMC6198525
OpenAlexW2898008166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.