Evidence map›Paper›PMID 30348099›Full record

ReviewBMC infectious diseases2018

Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review.

Jinjing Zhang, Xiaojing Yan, Yan Li, Ran Gao, Pingping Wang, Wenbin Mo

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jinjing ZhangDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Xiaojing YanDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China. yanxiaojing_pp@hotmail.com.
Yan LiDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Ran GaoDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Pingping WangDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Wenbin MoDepartment of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

Program for New Century Excellent Talents in University (CN) NCET-13-1037Subtopic of National Basic Research Program of China (973 program) 2013CB966803
6 · The paper itself

Abstract

backgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV), which is classified into the genus Phlebovirus and family Phenuiviridae. Reactive plasmacytosis mimicking multiple myeloma is a very rare condition in association with SFTS. Here, we describe two SFTS cases who presented with hyperimmunoglobulinemia, as well as extensive bone marrow and peripheral blood plasmacytosis, which mimicked multiple myeloma (MM). CASE PRESENTATION: We report two cases who presented with fever and blood routine abnormity which were conformed as SFTS eventually. They were performed bone marrow aspiration and were admitted to the department of hematology with a preliminary diagnosis of MM. They all had hyperimmunoglobulinemia, extensive bone marrow and peripheral blood plasma cells, prolonged activated partial thromboplastin time (APTT), elevated hepatic enzyme. The two patients recovered with treatment of doxycycline, human immunoglobulins, plasma transfusion, and other supporting treatments. But case 1 occurred lymphoma 8 months later and died.

conclusionSFTS might be one of differential diagnosis of MM in certain endemic area. We also conclude that SFTSV is a pantropic virus that could injure most tissues and cells of the human body.

Indexed as

AdultAnti-Bacterial AgentsAntibodies, ViralBone MarrowDiagnosis, DifferentialDoxycyclineFemaleHumansImmunoglobulinsMaleMiddle AgedMultiple MyelomaPhlebotomus FeverPhlebovirusRNA, ViralThrombocytopeniaAnti-Bacterial AgentsAntibodies, ViralDoxycyclineImmunoglobulinsRNA, ViralMultiple myelomaReactive plasmacytosisSevere fever with thrombocytopenia syndromeSFTS

Identifiers

PMID30348099
PMCPMC6198377
OpenAlexW2896857810

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.