Evidence map›Paper›PMID 30347935›Full record

ArticleJournal of neurogastroenterology and motility2018

The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?

Takahisa Yamasaki, Colin Hemond, Mohamed Eisa, Stephen Ganocy, Ronnie Fass

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06444347 (The Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair in Robotic Anti-Reflux Surgery), which is not on this map. Cited by 70 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06444347 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair in Robotic Anti-Reflux Surgery: A Multi-Institutional Randomized Trial

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2024 to 2030Enrolled200ConditionsHiatal HerniaArmsBiosynthetic Mesh, Hiatal Hernia Repair
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Prevalence and risk factors for gastroesophageal reflux disease in the Indian population: A meta-analysis and meta-regression study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Pooled it
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  15. Observational
  16. Gastrointestinal Conditions and New Diagnosis of Alcohol Use Disorder.Journal of the American Board of Family Medicine : JABFM · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Takahisa YamasakiThe Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Colin HemondDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Mohamed EisaDepartment of Internal Medicine, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.
Stephen GanocyCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.
Ronnie FassThe Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsGastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged and older people. Since risk factors for GERD affect a growing number of the adult population, concerns have been raised that increasingly younger people may develop GERD. We aim to determine if the proportion of younger patients has increased among the GERD population.

methodsThe incidence of GERD as well as several variables were evaluated during an 11-year period. Explorys was used to evaluate datasets at a "Universal" and Healthcare system in northern Ohio to determine if trends at a local level reflected those at a universal level. GERD patients were classified into 7 age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, and ≥ 70 years).

resultsThe proportion of patients with GERD increased in all age groups, except for those who were ≥ 70 years in the universal dataset (

conclusionOver the last decade, there has been a significant increase in the proportion of younger patients with GERD, especially those within the age range of 30-39 years.

Indexed as

AgeEpidemiologyGastroesophageal reflux diseaseProton pump inhibitors

Identifiers

PMID30347935
PMCPMC6175565

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.