Evidence map›Paper›PMID 30347827›Full record

ArticleInternational journal of molecular sciences2018

Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT

Jarosław Walory, Lidia Mielczarek, Małgorzata Jarończyk, Mirosława Koronkiewicz, Jerzy Kossakowski, Ryszard Bugno, Andrzej J Bojarski, Zdzisław Chilmonczyk

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jarosław WaloryDepartment of Drug Biotechnology and Bioinformatics, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. jwalory@gmail.com.pl.ORCID 0000-0003-2352-2621
Lidia MielczarekDepartment of Drug Biotechnology and Bioinformatics, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. l.mielczarek@nil.gov.pl.
Małgorzata JarończykDepartment of Drug Biotechnology and Bioinformatics, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. mjaronczyk@gmail.com.
Mirosława KoronkiewiczDepartment of Drug Biotechnology and Bioinformatics, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. m.koronkiewicz@nil.gov.pl.
Jerzy KossakowskiWarsaw University of Medicine, Banacha 1, 02-097 Warsaw, Poland. jerzy.kossakowski@wum.edu.pl.
Ryszard BugnoDepartment of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Cracow, Poland. bugno@if-pan.krakow.pl.ORCID 0000-0003-3741-674X
Andrzej J BojarskiDepartment of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Cracow, Poland. bojarski@if-pan.krakow.pl.ORCID 0000-0003-1417-6333
Zdzisław ChilmonczykDepartment of Drug Biotechnology and Bioinformatics, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland. z.chilmonczyk@nil.gov.pl.
Narodowy Instytut Leków · PLMaj Institute of Pharmacology · PLMedical University of Warsaw · PL

Funding

VALIDATION OF A MULTIPLEXED ASSAY FOR BLADDER CANCER DIAGNOSISR01CA198887 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI ROSSER, CHARLES J · 2016 to 2025
$6.8M
Norwegian Financial Mechanism 2009-2014 PLATFORMex (Pol-Nor/198887/73/2013)
6 · The paper itself

Abstract

The cytotoxic activity of several serotonin transporter (SERT) inhibitors and subtype of serotonin receptor 1A (5-HT

Indexed as

3T3 CellsAnimalsCarcinogenesisCell Line, TumorHEK293 CellsHumansMiceMice, Inbred BALB CMolecular Docking SimulationProtein BindingReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Plasma Membrane Transport ProteinsReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Plasma Membrane Transport Proteins5-HT1A receptorapoptosiscancercytotoxic activityPC-3S14506serotonin ligandsSH-SY5YSSRI

Identifiers

PMID30347827
PMCPMC6214143
OpenAlexW2896732680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.