ArticleBiosensors2018
An Aptamer-Based Capacitive Sensing Platform for Specific Detection of Lung Carcinoma Cells in the Microfluidic Chip.
Article in Biosensors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Review of Microchip Analytical Methods Coupled with Aptamer-Based Signal Amplification Strategies for High-Sensitivity Bioanalytical Applications.Biosensors · 2025Review
- Electrochemical and Optical Multi-Detection ofBiosensors · 2024Article
- Parylene Double-Layer Coated Screen-Printed Carbon Electrode for Label-Free and Reagentless Capacitive Aptasensing of Gliadin.ACS sensors · 2024Article
- The effect of magnetic bead size on the isolation efficiency of lung cancer cells in a serpentine microchannel with added cavities.Biomedical microdevices · 2024Article
- Based on mutated aptamer-smartphone colorimetric detection of metronidazole in milk.Frontiers in bioengineering and biotechnology · 2024Article
- Metallic Nanowires Self-Assembled in Quasi-Circular Nanomolds Templated by DNA Origami.International journal of molecular sciences · 2023Article
- Microfluidic-Chip-Integrated Biosensors for Lung Disease Models.Biosensors · 2021Review
- Effective Isolation for Lung Carcinoma Cells Based on Immunomagnetic Separation in a Microfluidic Channel.Biosensors · 2021Article
- Biosensors-on-Chip: An Up-to-Date Review.Molecules (Basel, Switzerland) · 2020Review
- An integrated microfluidic platform for selective and real-time detection of thrombin biomarkers using a graphene FET.The Analyst · 2020Article
- Combining impedance biosensor with immunomagnetic separation for rapid screening of Salmonella in poultry supply chains.Poultry science · 2020Article
- Lab-on-a-Chip Systems for Aptamer-Based Biosensing.Micromachines · 2020Review
- Selective Detection of Human Lung Adenocarcinoma Cells Based on the Aptamer-Conjugated Self-Assembled Monolayer of Gold Nanoparticles.Micromachines · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Improvement of methods for reliable and early diagnosis of the cellular diseases is necessary. A biological selectivity probe, such as an aptamer, is one of the candidate recognition layers that can be used to detect important biomolecules. Lung cancer is currently a typical cause of cancer-related deaths. In this work, an electrical sensing platform is built based on amine-terminated aptamer modified-gold electrodes for the specific, label-free detection of a human lung carcinoma cell line (A549). The microdevice, that includes a coplanar electrodes configuration and a simple microfluidic channel on a glass substrate, is fabricated using standard photolithography and cast molding techniques. A procedure of self-assembly onto the gold surface is proposed. Optical microscope observations and electrical impedance spectroscopy measurements confirm that the fabricated microchip can specifically and effectively identify A549 cells. In the experiments, the capacitance element that is dominant in the change of the impedance is calculated at the appropriate frequency for evaluation of the sensitivity of the biosensor. Therefore, a simple, inexpensive, biocompatible, and selective biosensor that has the potential to detect early-stage lung cancer would be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.