Evidence map›Paper›PMID 30347752›Full record

ArticleNutrients2018

The Protective Effect of

Bongkyun Park, Ik Soo Lee, Soo-Wang Hyun, Kyuhyung Jo, Tae Gu Lee, Jin Sook Kim, Chan-Sik Kim

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05784519 (Clinical Study of Mesenchymal Stem Cell Eye Drops for Treating Dry Eye Disease), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05784519 early_phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation

Clinical Study of Mesenchymal Stem Cell Eye Drops for Treating Dry Eye Disease

TypeinterventionalSponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2023 to 2028Enrolled10ConditionsMesenchymal Stem Cell, Dry Eye SyndromesArmsMSCs eye drops
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. The Invasive SpeciesFrontiers in pharmacology · 2022
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Advances for pharmacological activities ofPharmaceutical biology · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Pluronic-F-127-Passivated SnOPlants (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. New Approaches on Japanese Knotweed (Plants (Basel, Switzerland) · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bongkyun ParkClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. bkpark@kiom.re.kr.
Ik Soo LeeHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. knifer48@kiom.re.kr.
Soo-Wang HyunHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. swhyun@kiom.re.kr.
Kyuhyung JoClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. jopd7414@kiom.re.kr.
Tae Gu LeeClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. berong35@kiom.re.kr.
Jin Sook KimHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. jskim@kiom.re.kr.
Chan-Sik KimClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea. chskim@kiom.re.kr.ORCID 0000-0001-7610-9887
Korea Institute of Oriental Medicine · KR

Funding

Ministry of Agriculture, Food and Rural Affairs 317033-03
6 · The paper itself

Abstract

Dry eyes are caused by highly increased osmolarity of tear film, inflammation, and apoptosis of the ocular surface. In this study, we investigated the effect of

Indexed as

AnimalsCell SurvivalCorneaDose-Response Relationship, DrugDry Eye SyndromesEpithelial CellsFallopia japonicaHumansLacrimal ApparatusMaleOsmolar ConcentrationPlant ExtractsRatsRats, WistarStress, PhysiologicalTearsPlant Extractsapoptosisdry eyeexorbital lacrimal gland-excisedhuman corneal epithelial cellshyperosmolar stressinflammationmatrix metallopeptidase 9 (MMP9)Mucin4oxidative stressPolygonum cuspidatum

Identifiers

PMID30347752
PMCPMC6212923
OpenAlexW2897316622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.