Evidence map›Paper›PMID 30347522›Full record

ReviewAngewandte Chemie (International ed. in English)2019

Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.

Yingying Geng, William J Peveler, Vincent M Rotello

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

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  19. Heliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yingying GengMolecular and Cellular Biology Program, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA, 01003, USA.
William J PevelerDivision of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, G12 8LT, UK.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA, 01003, USA.ORCID 0000-0002-5184-5439

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Recognition and Presentation of Alpha Helices using Nanoparticle ReceptorsR01GM077173 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2007 to 2018
$3.7M
Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
Nanosensor-Based Phenotypic Screening for Precision Therapy of Cancer Stem CellsR56CA207932 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MERCURIO, ARTHUR M, ROTELLO, VINCENT M. · 2017 to 2017
$300k
NCI NIH HHS R56 CA207932NIAID NIH HHS R01 AI134770NIGMS NIH HHS R01 GM077173NIGMS NIH HHS T32 GM008515NIH HHS CA207932NIH HHS GM077173Stockbridge School of Agriculture, University of Massachusetts Amherst GM008515
6 · The paper itself

Abstract

Array-based sensor "chemical nose/tongue" platforms are inspired by the mammalian olfactory system. Multiple sensor elements in these devices selectively interact with target analytes, producing a distinct pattern of response and enabling analyte identification. This approach offers unique opportunities relative to "traditional" highly specific sensor elements such as antibodies. Array-based sensors excel at distinguishing small changes in complex mixtures, and this capability is being leveraged for chemical biology studies and clinical pathology, enabled by a diverse toolkit of new molecular, bioconjugate and nanomaterial technologies. Innovation in the design and analysis of arrays provides a robust set of tools for advancing biomedical goals, including precision medicine.

Indexed as

Biosensing TechniquesDrug DiscoveryBiomedical ResearchHumansNanostructuresarray-based sensingbiomedicinecancer cell detectiondiagnosisprotein detection

Identifiers

PMID30347522
PMCPMC6800156

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.