Evidence map›Paper›PMID 30347190›Full record

ArticleExperimental neurology2019

Gene expression profiling in a mouse model of Dravet syndrome.

Nicole A Hawkins, Jeffrey D Calhoun, Alexandra M Huffman, Jennifer A Kearney

Abstract read
In one paragraph

Article in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
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  5. Review
  6. Review
  7. Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Fine mapping and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome.Annals of clinical and translational neurology · 2023
    Article
  16. Article
  17. Reduction ofFrontiers in neuroscience · 2023
    Article
  18. Article
  19. Fine mapping and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicole A HawkinsDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jeffrey D CalhounDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Alexandra M HuffmanDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jennifer A KearneyDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: jennifer.kearney@northwestern.edu.
Northwestern University · US

Funding

Genetic Modifiers of Childhood EpilepsyR01NS084959 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEARNEY, JENNIFER A · 2014 to 2024
$4.2M
NINDS NIH HHS R01 NS084959
6 · The paper itself

Abstract

Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a

Indexed as

Disease Models, AnimalAnimalsEpilepsies, MyoclonicGene Expression ProfilingMiceMice, 129 StrainMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelSpecies SpecificityNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseEpilepsyEpileptic encephalopathyGene expressionRNA-seqSeizureVoltage-gated sodium channel

Identifiers

PMID30347190
PMCPMC6287761
OpenAlexW2897313877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.