ArticleDevelopmental biology2018
Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Ascl1 promotes OPC specification across species and central nervous system regions and its gliogenic function is regulated by phosphorylation.Developmental biology · 2026Article
- Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence.Genes & development · 2025Article
- Demyelination and Remyelination: General Principles.Advances in neurobiology · 2025Review
- GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.PLoS biology · 2024Article
- Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review.Cellular and molecular neurobiology · 2023Review
- Oligodendrocyte origin and development in the zebrafish visual system.The Journal of comparative neurology · 2023Article
- Effects of the Notch Signaling Pathway on Secondary Brain Changes Caused by Spinal Cord Injury in Mice.Neurochemical research · 2022Article
- Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations.Developmental biology · 2021Article
- The Effects of the Olig Family on the Regulation of Spinal Cord Development and Regeneration.Neurochemical research · 2021Review
- The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.Communications biology · 2021Article
- Article
- Met is required for oligodendrocyte progenitor cell migration in Danio rerio.G3 (Bethesda, Md.) · 2021Article
- Review
- Low-Field Magnetic Stimulation Accelerates the Differentiation of Oligodendrocyte Precursor Cells via Non-canonical TGF-β Signaling Pathways.Molecular neurobiology · 2021Article
- Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.Scientific reports · 2021Article
- Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Glial Patchwork: Oligodendrocyte Progenitor Cells and Astrocytes Blanket the Central Nervous System.Frontiers in cellular neuroscience · 2021Review
- Proteome Profile of Myelin in the Zebrafish Brain.Frontiers in cell and developmental biology · 2021Article
- Complex crosstalk of Notch and Hedgehog signalling during the development of the central nervous system.Cellular and molecular life sciences : CMLS · 2021Review
- Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.PLoS biology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
During development of the central nervous system oligodendrocyte precursor cells (OPCs) give rise to both myelinating oligodendrocytes and NG2 glia, which are the most proliferative cells in the adult mammalian brain. NG2 glia retain characteristics of OPCs, and some NG2 glia produce oligodendrocytes, but many others persist throughout adulthood. Why some OPCs differentiate as oligodendrocytes during development whereas others persist as OPCs and acquire characteristics of NG2 glia is not known. Using zebrafish spinal cord as a model, we found that OPCs that differentiate rapidly as oligodendrocytes and others that remain as OPCs arise in sequential waves from distinct neural progenitors. Additionally, oligodendrocyte and persistent OPC fates are specified during a defined critical period by small differences in Shh signaling and Notch activity, which modulates Shh signaling response. Thus, our data indicate that OPCs fated to produce oligodendrocytes or remain as OPCs during development are specified as distinct cell types, raising the possibility that the myelinating potential of OPCs is set by graded Shh signaling activity.
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Registered trials
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