ArticleInvestigative ophthalmology & visual science2018
Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Multimodal Retinal Structural and Functional Tests Identify Local and Layer-Related Alterations in Early Type 2 Diabetes.Investigative ophthalmology & visual science · 2026Article
- Retinal Neurophysiological Parameters in Young Patients With Type 1 Diabetes.Investigative ophthalmology & visual science · 2026Article
- Brief report: harmonic analysis of the 30 Hz flicker ERG in early-stage diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Transient increase of flicker electroretinograms after combined cataract surgery and vitrectomy for idiopathic epiretinal membrane.Scientific reports · 2024Article
- The effects of time restricted feeding on age-related changes in the mouse retina.Experimental gerontology · 2024Article
- Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy: a cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Intrinsic signal optoretinography of dark adaptation abnormality due to rod photoreceptor degeneration.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Retinal Functional Impairment in Diabetic Retinopathy.Biomedicines · 2023Article
- Increasing Energetic Demands on Photoreceptors in Diabetes Corrects Retinal Lipid Dysmetabolism and Reduces Subsequent Microvascular Damage.The American journal of pathology · 2023Article
- Transient Increase of Flicker Electroretinography Amplitudes after Cataract Surgery: Association with Postoperative Inflammation.Ophthalmology science · 2023Article
- Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo.International journal of molecular sciences · 2023Review
- Discriminating early-stage diabetic retinopathy with subjective and objective perimetry.Frontiers in endocrinology · 2023Article
- Preventing diabetic retinopathy by mitigating subretinal space oxidative stressVisual neuroscience · 2020Review
- Electrophysiological measures of dysfunction in early-stage diabetic retinopathy: No correlation between cone phototransduction and oscillatory potential abnormalities.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- Nonlinearities in the flicker electroretinogram: A tool for studying retinal dysfunction applied to early-stage diabetic retinopathy.Vision research · 2019Article
- Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram.Investigative ophthalmology & visual science · 2019Article
- Clinical electroretinography in diabetic retinopathy: a review.Survey of ophthalmologyReview
- Clinical Evidence of a Photoreceptor Origin in Diabetic Retinal Disease.Ophthalmology scienceReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Purpose: To define the nature and extent of temporal frequency abnormalities in diabetics who have mild or no nonproliferative diabetic retinopathy (NPDR) by using the flicker electroretinogram (ERG). Methods: Light-adapted flicker ERGs were recorded from 20 diabetics who have no clinically apparent retinopathy, 20 diabetics who have mild NPDR, and 20 nondiabetic, age-equivalent controls. ERGs were elicited by full-field sinusoidal flicker across the temporal frequency range of 6 to 100 Hz and were recorded using conventional techniques. The amplitude and phase of the fundamental and harmonic response components were derived by Fourier analysis and compared among the groups. Results: Analysis of variance indicated that compared with the controls, both patient groups had significant amplitude reductions of the fundamental ERG component for temporal frequencies greater than 56 Hz (all P ≤ 0.03). Modeling the amplitude measurements indicated that both patient groups had significant reductions in the high-frequency response cutoff. Response phase, however, did not differ significantly among the groups at any frequency. The amplitude and phase of the high-frequency harmonics (32-96 Hz) of the patients' responses to a low-frequency stimulus (16 Hz) were normal over the temporal frequency range that the fundamental response was abnormal. Conclusions: Taken together, the diabetics' fundamental amplitude attenuation for rapid flicker combined with their normal high-frequency harmonic responses generated by slow flicker suggest that the likely site of the abnormal temporal filtering occurs prior to the nonlinearity that generates the harmonic components of the ERG, implicating a photoreceptor origin.
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