ArticleJAMA otolaryngology-- head & neck surgery2018
Association of Facility Volume With Positive Margin Rate in the Surgical Treatment of Head and Neck Cancer.
Article in JAMA otolaryngology-- head & neck surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Outcomes of malignant orbital tumors: a 22-year Norwegian single-center series.Frontiers in surgery · 2026Article
- Intraoperative fluorescence in solid head and neck cancer: A scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Facility Type Predicts Treatment Regimen for Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Elective Neck Dissection in cT1-4 N0M0 Head and Neck Spindle Cell Carcinoma.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Volume Outcome Relationships of Oropharyngeal Cancer Patients Undergoing Transoral Robotic Surgery.The Laryngoscope · 2025Article
- Exploratory Qualitative Analysis of Needs Assessment and Obstacles Faced by Head and Neck Cancer Patients in Central Pennsylvania.Laryngoscope investigative otolaryngology · 2025Article
- The Use of Fluorescent Markers to Detect and Delineate Head and Neck Cancer: A Scoping Review.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Choice of Adjuvant Radiotherapy Facility in Sinonasal Squamous Cell Carcinoma.The Laryngoscope · 2025Article
- How far are we off? Analyzing the accuracy of surgical margin relocation in the head and neck.Head & neck · 2024Article
- Comparison of surgical margins and adjuvant therapy for head and neck cancer by hospital type.Translational cancer research · 2024Article
- Illuminating the future of precision cancer surgery with fluorescence imaging and artificial intelligence convergence.NPJ precision oncology · 2024Review
- Personalised Medicine and the Potential Role of Electrospinning for Targeted Immunotherapeutics in Head and Neck Cancer.Nanomaterials (Basel, Switzerland) · 2023Review
- Eugene Nicholas Myers' Lecture on Head and Neck Cancer, 2020: The Surgeon as a Prognostic Factor in Head and Neck Cancer Patients Undergoing Surgery.International archives of otorhinolaryngology · 2023Article
- Variance in 3D anatomic localization of surgical margins based on conventional margin labeling in head and neck squamous cell carcinoma.Oral oncology · 2023Article
- Quantifying Tumor and Vasculature Deformations during Laryngoscopy.Annals of biomedical engineering · 2022Article
- Article
- Do Microsurgical Outcomes Differ Based on Which Specialty Does the Operation? A NSQIP Analysis.Plastic and reconstructive surgery. Global open · 2020Article
- Margin Analysis in Head and Neck Cancer: State of the Art and Future Directions.Annals of surgical oncology · 2019Review
- Prognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma.JAMA otolaryngology-- head & neck surgery · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: The achievement of complete tumor resection with tumor-free margins is one of the main principles of oncologic surgery for head and neck squamous cell carcinoma (HNSCC). The negative prognostic influence of a positive margin (PM) across all head and neck subsites has been well established. National guidelines recommend the use of adjuvant chemoradiation therapy (CRT) in the setting of PM. Objective: To determine the incidence of PM in HNSCC across multiple subsites, as well as the factors associated with its occurrence. Design, Setting, and Participants: This retrospective cohort study used the National Cancer Database to identify patients diagnosed with HNSCC between 2010 and 2014 and who underwent surgical resection (n = 28 840). Main Outcomes and Measures: Predictors of PM rate and likelihood to receive adjuvant CRT. Results: Among the 28 840 patients included in this study, 19 727 (68.4 %) were men, and the average age was 62.4 years (range, 40 to ≥90 years). In univariable analysis, a lower PM rate was associated with higher facility volume (26.3% for the lowest volume quartile, 16.5% for the middle 2 quartiles, and 10.8% for the highest volume quartile) and treatment at academic vs nonacademic facilities (14.0% vs 22.7%). In multivariate analysis, those treated at higher-volume facilities remained significantly less likely to have PM (adjusted odds ratio, 0.85; 95% CI, 0.83-0.88). The trend of decreasing PM rate with increasing facility volume was observed in both academic (aOR, 0.88 per 10-case volume increase [95% CI, 0.85-0.91]) and nonacademic (aOR, 0.73 per 10-case volume increase [95% CI, 0.68-0.80]) facilities. There was no association between facility volume and patient likelihood of receiving adjuvant CRT in the setting of PM (compared with CCPs: aOR, 0.98 per 10-case volume increase [95% CI, 0.84-1.14] for CCCPs; and aOR, 1.24 [95% CI, 0.99-1.55] for INCPs). Conclusions and Relevance: These findings suggest that high-volume facilities are associated with lower rates of PM in the surgical treatment of HNSCC in both academic and nonacademic settings. Facility volume for head and neck oncologic surgeries may be considered a benchmark for quality of care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.