ArticlePLoS genetics2018
Deleterious variation shapes the genomic landscape of introgression.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed.
- Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population.Nature ecology & evolution · 2026Article
- Population Decline, Inbreeding and Hybridization Shape the Genetic Vulnerability of a Critically Endangered Seabird.Molecular ecology · 2026Article
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- Introgression and Divergence in a Young Species Group.Molecular ecology · 2026Article
- Deep learning reveals genomic regions introgressed between two recurrently hybridizing lynx species.Molecular biology and evolution · 2026Article
- Interbreeding between Neanderthals and modern humans was strongly sex biased.Science (New York, N.Y.) · 2026Article
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Genetic rescue of Florida panthers reduced homozygosity but did not swamp ancestral genotypes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrating population genomics and environmental data to predict adaptation to climate change in post-bottleneck Tibetan macaques.Science advances · 2025Article
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- Adaptive Introgression as an Evolutionary Force: A Meta-Analysis of Knowledge Trends.Evolutionary applications · 2025Article
- Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations.bioRxiv : the preprint server for biology · 2025Article
- Repeated Mitochondrial Capture With Limited Genomic Introgression in a Lizard Group.Molecular ecology · 2025Article
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes.Molecular ecology · 2024Article
- Evolution of the Correlated Genomic Variation Landscape Across a Divergence Continuum in the Genus Castanopsis.Molecular biology and evolution · 2024Article
- Constraining models of dominance for nonsynonymous mutations in the human genome.PLoS genetics · 2024Article
- Revisiting Dominance in Population Genetics.Genome biology and evolution · 2024Review
- The evolutionary dynamics of local adaptations under genetic rescue is determined by mutational load and polygenicity.The Journal of heredity · 2024Article
- Selection Shapes the Genomic Landscape of Introgressed Ancestry in a Pair of Sympatric Sea Urchin Species.Genome biology and evolution · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
While it is appreciated that population size changes can impact patterns of deleterious variation in natural populations, less attention has been paid to how gene flow affects and is affected by the dynamics of deleterious variation. Here we use population genetic simulations to examine how gene flow impacts deleterious variation under a variety of demographic scenarios, mating systems, dominance coefficients, and recombination rates. Our results show that admixture between populations can temporarily reduce the genetic load of smaller populations and cause increases in the frequency of introgressed ancestry, especially if deleterious mutations are recessive. Additionally, when fitness effects of new mutations are recessive, between-population differences in the sites at which deleterious variants exist creates heterosis in hybrid individuals. Together, these factors lead to an increase in introgressed ancestry, particularly when recombination rates are low. Under certain scenarios, introgressed ancestry can increase from an initial frequency of 5% to 30-75% and fix at many loci, even in the absence of beneficial mutations. Further, deleterious variation and admixture can generate correlations between the frequency of introgressed ancestry and recombination rate or exon density, even in the absence of other types of selection. The direction of these correlations is determined by the specific demography and whether mutations are additive or recessive. Therefore, it is essential that null models of admixture include both demography and deleterious variation before invoking other mechanisms to explain unusual patterns of genetic variation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.