ArticlePLoS neglected tropical diseases2018
Efficacy comparison between long-term high-dose praziquantel and surgical therapy for cerebral sparganosis: A multicenter retrospective cohort study.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Current status, challenges and control of human sparganosis worldwide: a scoping review.Infectious diseases of poverty · 2026Article
- Evaluation of the diagnostic value of metagenomic next-generation sequencing for zoonotic cestodeFood and waterborne parasitology · 2026Article
- Cerebral Sparganosis: A Case Report of Rare Parasitic Brain Infection.Brain tumor research and treatment · 2026Article
- The clinical, neuroradiological, and pathological features of cerebral sparganosis in Jiangxi Province, China.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Chromosome-Contiguous Reference Genome forInternational journal of molecular sciences · 2025Article
- Recent update on cerebral sparganosis: A bibliometric analysis and scientific mapping.Narra J · 2024Article
- Annexin gene family in Spirometra mansoni (Cestoda: Diphyllobothriidae) and its phylogenetic pattern among Platyhelminthes of medical interest.Parasite (Paris, France) · 2024Article
- Cerebral sparganosis in a child with corpus callosum invasion: a case report.BMC infectious diseases · 2023Article
- The serum IgG antibody level as a biomarker for clinical outcome in patients with cerebral sparganosis after treatment.Frontiers in immunology · 2023Article
- Editorial: Expert opinions and perspectives in immunity to worms infection: 2022.Frontiers in immunology · 2023Article
- Diagnosis and management of cerebral sparganosis: An uncommon parasitic infection of the brain.Radiology case reports · 2022Article
- Molecular Characterization and Phylogenetic Analysis ofVeterinary sciences · 2022Article
- Case Report: Moving Tumor-Like Foci Behind Refractory Epilepsy-Cerebral Sparganosis Successfully Treated by Surgery After Failure of Praziquantel Treatment.Frontiers in neurology · 2022Article
- A Human Case of Lumbosacral Canal Sparganosis in China.The Korean journal of parasitology · 2021Article
- Identification of an enolase gene and its physiological role in Spirometra mansoni.Parasitology research · 2021Article
- Case Report: Management of Dead Intraocular Helminth Parasites in Asymptomatic Patients.The American journal of tropical medicine and hygiene · 2020Article
- Large-scale survey of a neglected agent of sparganosis Spirometra erinaceieuropaei (Cestoda: Diphyllobothriidae) in wild frogs in China.PLoS neglected tropical diseases · 2020Article
- Case Report: Human Subcutaneous Sparganosis in a Thai Migrant.The American journal of tropical medicine and hygiene · 2019Article
- Cerebral sparganosis presenting with atypical postcontrast magnetic resonance imaging findings: a case report and literature review.BMC infectious diseases · 2019Review
- Mons pubis Sparganosis infection: A case report.Medicine internationalArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSparganosis is a parasitic infection caused by the plerocercoid larvae of Spirometra mansoni in East and Southeast Asia. The plerocercoid larvae sometimes invade the encephalon, resulting in severe cerebral sparganosis. Surgical removal of the larvae is considered a standard therapy for cerebral sparganosis. In contrast, the efficacy and safety of long-term, high-dose praziquantel treatment for cerebral sparganosis have not been explored. METHODOLOGY/PRINCIPAL
findingsIn this multicenter retrospective study, we assessed the records of 96 patients with cerebral sparganosis who consulted at three medical centers from 2013 to 2017. Forty-two patients underwent surgical lesion removal, and the other 54 patients received long-term, high-dose praziquantel (50 mg/kg/day for 10 days, repeated at monthly intervals). The primary outcome was the complete disappearance of active lesions on cerebral magnetic resonance imaging. The secondary outcomes included the modified Rankin scale score at 90 days, incidence of seizure, eosinophil count, and serological Spirometra. mansoni antibody titer. The efficacy of praziquantel treatment was similar to that of surgical lesion removal for cerebral sparganosis with respect to both the primary outcome and secondary outcomes. Although binary logistic regression models also supported the primary outcome after adjustment for age, sex, lesion location, and loss to follow-up, some unavoidable confounders might have biased the statistical power. No significant clinical complications or laboratory side effects occurred in the praziquantel group with the exception of a relatively benign allergic reaction. CONCLUSIONS/SIGNIFICANCE: In this small-sample, nonrandomized, retrospective exploratory study, some patients with cerebral sparganosis were responsive to long-term, high-dose praziquantel with an efficacy similar to that of surgical lesion removal. These findings increase the treatment flexibility for this serious infection.
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