Evidence map›Paper›PMID 30346891›Full record

ArticleRegenerative medicine2018

Cytokines in umbilical cord blood-derived cellular product: a mechanistic insight into bone repair.

Mukta S Sane, Neha Misra, Omid Mohammad Mousa, Steve Czop, Huiyuan Tang, Larry T Khoo, Christopher D Jones, Soumyajit Banerjee Mustafi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Cell Sources for Human In vitro Bone Models.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mukta S SaneDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
Neha MisraDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
Omid Mohammad MousaDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
Steve CzopDepartment of Regulatory & Medical Affairs, Burst Biologics, Boise, ID 83705, USA.
Huiyuan TangDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
Larry T KhooThe Spine Clinic of Los Angeles, Good Samaritan Hospital, University of Southern California, Los Angeles, CA 90017, USA.
Christopher D JonesDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
Soumyajit Banerjee MustafiDepartment of Research & Development, Burst Biologics, Boise, ID 83705, USA.
GTx (United States) · USBoise State University · USUniversity of Southern California · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
NIGMS NIH HHS P20 GM103408NIH HHS P20GM103408
6 · The paper itself

Abstract

aimUmbilical cord blood (UCB) finds frequent applications in regenerative medicine. We evaluated the role of cytokines present in a uniquely processed, UCB-derived cellular allograft product (UCBp). MATERIALS &

methodsLuminex multiplex assay and standard cell biology methods were employed.

resultsStudy with allografts from 33 donors identified 44 quantifiable cytokines in the UCBp derived conditioned media (CM). The UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells. Moreover, UCBp-CM induced secretion of VEGF-A and osteoprotegerin, which promoted angiogenesis of endothelial cells and positively influenced the osteogenic differentiation of MSCs, respectively.

conclusionCytokines in UCBp stimulate cellular processes important for bone regeneration, making UCBp an excellent candidate for potential applications in orthopedic procedures like bone non-union and spinal fusion.

Indexed as

Bone RegenerationAllograftsCell MovementCell ProliferationCellular MicroenvironmentCord Blood Stem Cell TransplantationCulture Media, ConditionedCytokinesFetal BloodHumansHuman Umbilical Vein Endothelial CellsNeovascularization, PhysiologicRegenerative MedicineCulture Media, ConditionedCytokinesangiogenesisbone non-unioncell signalingmigrationosteogenic differentiationproliferationspinal fusion

Identifiers

PMID30346891
PMCPMC6439518
OpenAlexW2896690136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.