ArticlePhotomedicine and laser surgery2018
Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial.
5 registry-linked trialsAbstract read
In one paragraph
Article in Photomedicine and laser surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Intrapartum Depression Using Non-invasive Photobiomodulation
Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder: A Study of Dosing With Laser
Safety and Efficacy of Transcranial Photobiomodulation (tPBM) for Individuals With Autism Spectrum Disorder and Epileptiform Activity
Randomized, Sham-Controlled Trial of Transcranial Photobiomodulation for Major Depressive Disorder With PET and EEG Biomarker Outcomes.
Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Devices used for photobiomodulation of the brain-a comprehensive and systematic review.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.Photobiomodulation, photomedicine, and laser surgery · 2023Pooled it
- Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2023Pooled it
- Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial.Lasers in medical science · 2025Trial
- Dose-dependent effects of transcranial photobiomodulation on brain temperature in patients with major depressive disorder: a spectroscopy study.Lasers in medical science · 2024Trial
- Longitudinal study of impact of medication for opioid use disorder on Hamilton Depression Rating Scale.Journal of affective disorders · 2022Trial
- Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study.Photobiomodulation, photomedicine, and laser surgery · 2019Trial
- Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction.Lasers in surgery and medicine · 2019Trial
- Dose dependent effects of transcranial photobiomodulation on blood-oxygenation-level-dependent power in major depressive disorder.Brain stimulationTrial
- [A simulation study of photothermal effects in transcranial photobiomodulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Feasibility of Multi-Wavelength LED Irradiation on the Skull and Preliminary Glycemic Outcomes in Individuals with Type 2 Diabetes: A Prospective Pilot Study.Life (Basel, Switzerland) · 2026Article
- Imaging brain energetics to advance metabolic psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Exploring photobiomodulation as a complementary approach for mental health: an integrative review.Lasers in medical science · 2025Review
- A high-power near-infrared photobiomodulation device: design, fabrication, and primary impact on treatment-resistant depression.Lasers in medical science · 2025Article
- PBM alleviates depression and anxiety like behaviors in mice: insight from local field potential.Behavioral and brain functions : BBF · 2025Article
- Simulation-based dosimetry of transcranial and intranasal photobiomodulation of the human brain: the roles of wavelength, power density, and skin tone.Biomedical optics express · 2025Article
- Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Controlled Trial Investigating Dose-Dependent Effects.Journal of clinical medicine · 2025Article
- Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms.NeuroSci · 2025Review
- Article
- The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Paolo CassanoDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Samuel R PetrieDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
David MischoulonDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Cristina CusinDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Husam KatnaniDepartment of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.
Albert YeungDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Luis De TaboadaLiteCure LLC, Newark, Delaware.
Abigal ArchibaldDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Eric BuiCenter for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Massachusetts.
Lee BaerDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Trina ChangDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Justin ChenDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Paola PedrelliDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Lauren FisherDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Amy FarabaughDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts.
Jonathan E AlpertDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Maurizio FavaDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Dan V IosifescuAdult Psychopharmacology Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Funding
Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8MSynergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462kNIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
Abstract
PubMed holds no abstract for this paper.
Indexed as
Double-Blind MethodHumansLow-Level Light TherapyMajor Depressive DisorderPilot ProjectsRandomized Controlled Trials as Topicdepressionlow-level laser therapyrandomized controlled trial
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04404231ClinicalTrials.gov
NCT05435820ClinicalTrials.gov
NCT06352372ClinicalTrials.gov
NCT06934135ClinicalTrials.gov
NCT07736092ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.