Evidence map›Paper›PMID 30346689›Full record

ArticleACS chemical biology2018

Selective Usage of Isozymes for Stress Response.

Yugang Zhang, Zhewang Lin, Miao Wang, Hening Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Unbalance between Pyridine Nucleotide Cofactors in The SOD1 Deficient YeastInternational journal of molecular sciences · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yugang ZhangHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.
Zhewang LinHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.ORCID 0000-0003-1301-6661
Miao WangHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.
Hening LinHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.ORCID 0000-0002-0255-2701
Howard Hughes Medical Institute · US

Funding

Diphthamide biosynthesisR01GM088276 · NIGMS · CORNELL UNIVERSITY · PI LIN, HENING · 2009 to 2017
$2.5M
Acquisition of a Hybrid Quadrupole Time of Flight LC-MS/MS System for the CornellS10OD017992 · OD · CORNELL UNIVERSITY · PI ZHANG, SHENG · 2014 to 2014
$600k
NIGMS NIH HHS R01 GM088276NIH HHS S10 OD017992
6 · The paper itself

Abstract

Isozymes are enzymes with similar sequences that catalyze the same reaction in a given species. In Saccharomyces cerevisiae, most isozymes have major isoforms with high expression levels and minor isoforms with little expression under normal growth conditions. In a proteomic study aimed at identifying yeast protein regulated by rapamycin, we found an interesting phenomenon, that, for several metabolic enzymes, the major isozymes are downregulated while the minor isozymes are upregulated. Through enzymological and biochemical studies, we demonstrate that a rapamycin-upregulated enolase isozyme (ENO1) favors gluconeogenesis and a rapamycin-upregulated alcohol dehydrogenase isozyme (ALD4) promotes the reduction of NAD

Indexed as

Aldehyde DehydrogenaseAldehyde OxidoreductasesGene Expression RegulationGluconeogenesisIsoenzymesNADPhosphopyruvate HydrataseProtein Kinase InhibitorsProteomeProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSirolimusStress, PhysiologicalTranscription FactorsALD4 protein, S cerevisiaeAldehyde Dehydrogenasealdehyde dehydrogenase (NAD(P)+)Aldehyde OxidoreductasesENO1 protein, S cerevisiaeIsoenzymesNADPhosphopyruvate HydrataseProtein Kinase InhibitorsProteomeSaccharomyces cerevisiae ProteinsSirolimusTORC1 protein complex, S cerevisiaeTranscription Factors

Identifiers

PMID30346689
PMCPMC6893876
OpenAlexW2896692266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.