Evidence map›Paper›PMID 30346652›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Hybrid resistance to parental bone marrow grafts in nonlethally irradiated mice.

Benedikt Mahr, Nina Pilat, Nicolas Granofszky, Mario Wiletel, Moritz Muckenhuber, Svenja Maschke, Karin Hock, Thomas Wekerle

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Distinct roles for major and minor antigen barriers in chimerism-based tolerance under irradiation-free conditions.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  5. Review
  6. Hybrid resistance to parental bone marrow grafts in nonlethally irradiated mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Benedikt MahrSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5255-381X
Nina PilatSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4071-9397
Nicolas GranofszkySection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Mario WiletelSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Moritz MuckenhuberSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Svenja MaschkeSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Karin HockSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Thomas WekerleSection of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5159-2796
Medical University of Vienna · AT

Funding

Austrian Science Fund DK W1212-B13Austrian Science Fund TRP 151
6 · The paper itself

Abstract

Resistance to parental bone marrow (BM) grafts in F1 hybrid recipients is due to natural killer (NK) cell-mediated rejection triggered through "missing self" recognition. "Hybrid resistance" has usually been investigated in lethally irradiated F1 recipients in conjunction with pharmacological activation of NK cells. Here, we investigated BM-directed NK-cell alloreactivity in settings of reduced conditioning. Nonlethally irradiated (1-3 Gy) or nonirradiated F1 (C57BL6 × BALB/c) recipient mice received titrated doses (5-20 x 10

Indexed as

AnimalsBone MarrowBone Marrow TransplantationFemaleGraft RejectionImmune ToleranceKiller Cells, NaturalMaleMiceMice, Inbred BALB CMice, Inbred C57BLTransplantation Chimeraanimal models: murinebasic (laboratory) research/sciencebone marrow/hematopoietic stem cell transplantationimmunobiologyinnate immunitynatural killer (NK) cells/NK receptorsrejectiontolerance: chimerism

Identifiers

PMID30346652
PMCPMC6492153
OpenAlexW2895832849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.