ArticleSleep2019
Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Distinct Convergent Brain Alterations in Sleep Disorders and Sleep Deprivation: A Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Effects of solriamfetol in a long-term trial of participants with obstructive sleep apnea who are adherent or nonadherent to airway therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Microvascular Disease in the Hippocampus in Obstructive Sleep Apnoea.Clocks & sleep · 2026Article
- Hippocampal atrophy in untreated de novo Parkinson's disease with obstructive sleep apnea.NPJ Parkinson's disease · 2026Article
- Obstructive sleep apnea risk is associated with a diminished cognitive profile: findings from the Canadian longitudinal study on aging.Frontiers in psychology · 2026Article
- Limited Microvascular Remodelling Occurs in the Aged Human Hippocampus in Obstructive Sleep Apnoea.International journal of molecular sciences · 2025Article
- Article
- Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids.Genome research · 2025Article
- Examining the association between sleep apnea and total hippocampal volumes in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids.bioRxiv : the preprint server for biology · 2024Article
- Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance.BMC psychiatry · 2024Article
- Respiratory Dysfunction in Alzheimer's Disease-Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions.International journal of molecular sciences · 2024Review
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Clinical phenotypes of obstructive sleep apnea: a cluster analysis based on sleep perception and sleep quality.Sleep & breathing = Schlaf & Atmung · 2023Article
- Association of Sleep-Disordered Breathing and Medial Temporal Lobe Atrophy in Cognitively Unimpaired Amyloid-Positive Older Adults.Neurology · 2023Article
- Treatment of hypertension and obstructive sleep apnea counteracts cognitive decline in common neurocognitive disorders in diagnosis-related patterns.Scientific reports · 2023Article
- Cortical thickness and hippocampal volume in adolescent children with obstructive sleep apnea.Sleep · 2023Article
- Pterostilbene mediates glial and immune responses to alleviate chronic intermittent hypoxia-induced oxidative stress in nerve cells.PloS one · 2023Article
- Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea.Frontiers in neurology · 2023Article
- Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer's disease.Nature communications · 2022Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea (OSA) is commonly associated with memory impairments. Although MRI studies have found volumetric differences in the hippocampus of people with OSA compared with controls, MRI lacks the spatial resolution to detect changes in the specific regions of the hippocampus that process different types of memory. The present study performed histopathological investigations on autopsy brain tissue from 32 people with OSA (17 females and 15 males) to examine whether the thickness and myelination of the hippocampus and entorhinal cortex (EC) vary as a function of OSA severity. Increasing OSA severity was found to be related to cortical thinning in the molecular layer of the dentate gyrus (r2 = 0.136, p = 0.038), the CA1 (overall, r2 = 0.135, p = 0.039; layer 1, r2 = 0.157, p = 0.025; layer 2, r2 = 0.255, p = 0.003; and layer 3, r2 = 0.185, p = 0.014) and in some layers of the EC (layer 1, r2 = 0.186, p = 0.028; trend in layer 3, r2 = 0.124, p = 0.078). OSA severity was also related to decreased myelin in the deep layers but not the superficial layers of the EC (layer 6, r2 = 0.282, p = 0.006; deep white matter, r2 = 0.390, p = 0.001). Patients known to have used continuous positive airway pressure (CPAP) treatment showed no significant reductions in cortical thickness when compared with controls, suggesting that CPAP had a protective effect. However, CPAP did not protect against myelin loss. The regions of decreased cortical thickness and demyelination are locations of synaptic connections in both the polysynaptic (episodic and spatial) and direct (semantic) memory pathways and may underpin the impairments observed in episodic, semantic, and spatial memory in people with OSA.
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