Evidence map›Paper›PMID 30346573›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2019

Association of Previous Measles Infection With Markers of Acute Infectious Disease Among 9- to 59-Month-Old Children in the Democratic Republic of the Congo.

Hayley R Ashbaugh, James D Cherry, Nicole A Hoff, Reena H Doshi, Vivian H Alfonso, Adva Gadoth, Patrick Mukadi, Stephen G Higgins, Roger Budd, Christina Randall and 4 more

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In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hayley R AshbaughDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
James D CherryDavid Geffen School of Medicine, University of California, Los Angeles.
Nicole A HoffDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
Reena H DoshiDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
Vivian H AlfonsoDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
Adva GadothDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
Patrick MukadiSchool of Medicine, Kinshasa University, Democratic Republic of the Congo.
Stephen G HigginsOpGen Incorporated, Gaithersburg, Maryland.
Roger BuddDynex Technologies Incorporated, Chantilly, Virginia.
Christina RandallDynex Technologies Incorporated, Chantilly, Virginia.
Emile Okitolonda-WemakoyKinshasa School of Public Health, Democratic Republic of the Congo.
Jean Jacques Muyembe-TamfumNational Institute for Biomedical Research, Kinshasa, Democratic Republic of the Congo.
Sue K GerberBill and Melinda Gates Foundation, Seattle, Washington.
Anne W RimoinDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransient immunosuppression and increased susceptibility to other infections after measles infection is well known, but recent studies have suggested the occurrence of an "immune amnesia" that could have long-term immunosuppressive effects.

methodsWe examined the association between past measles infection and acute episodes of fever, cough, and diarrhea among 2350 children aged 9 to 59 months whose mothers were selected for interview in the 2013-2014 Democratic Republic of the Congo (DRC) Demographic and Health Survey (DHS). Classification of children who had had measles was completed using maternal recall and measles immunoglobulin G serostatus obtained via dried-blood-spot analysis with a multiplex immunoassay. The association with time since measles infection and fever, cough, and diarrhea outcomes was also examined.

resultsThe odds of fever in the previous 2 weeks were 1.80 (95% confidence interval [CI], 1.25-2.60) among children for whom measles was reported compared to children with no history of measles. Measles vaccination demonstrated a protective association against selected clinical markers of acute infectious diseases.

conclusionOur results suggest that measles might have a long-term effect on selected clinical markers of acute infectious diseases among children aged 9 to 59 months in the DRC. These findings support the immune-amnesia hypothesis suggested by others and underscore the need for continued evaluation and improvement of the DRC's measles vaccination program.

Indexed as

BiomarkersChild, PreschoolDemocratic Republic of the CongoDiarrheaHumansImmunization ProgramsImmunoglobulin GImmunosuppression TherapyInfantInfectionsMeaslesVaccinationBiomarkersImmunoglobulin Gcoughdiarrheafeverimmunosuppressionmeasles

Identifiers

PMID30346573
PMCPMC6933309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.