ArticleMagnetic resonance in medicine2019
Assessment of flip angle-TR equivalence for standardized dissolved-phase imaging of the lung with hyperpolarized 129Xe MRI.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Feasibility and SNR Performance of HyperpolarizedMagnetic resonance in medicine · 2026Article
- Actuated dose delivery and physiological monitoring ofMagma (New York, N.Y.) · 2026Article
- Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025Article
- Establishing standardized healthy reference distributions and values for multisiteMagnetic resonance in medicine · 2025Article
- Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025Review
- Mapping the amplitude and phase of dissolvedMagnetic resonance in medicine · 2025Article
- Assessment of pulmonary physiological changes caused by aging, cigarette smoking, and COPD with hyperpolarizedEuropean radiology · 2024Article
- Functional gas exchange measures onFrontiers in medicine · 2024Article
- Simultaneous quantification of hyperpolarized xenon-129 ventilation and gas exchange with multi-breath xenon-polarization transfer contrast (XTC) MRI.Magnetic resonance in medicine · 2023Article
- Establishing a hemoglobin adjustment forMagnetic resonance in medicine · 2023Article
- Investigating the impact of RF saturation-pulse parameters on compartment-selective gas-phase depolarization with xenon polarization transfer contrast MRI.Magnetic resonance in medicine · 2022Article
- Preclinical MRI Using HyperpolarizedMolecules (Basel, Switzerland) · 2022Review
- Noninvasive diagnosis of pulmonary hypertension with hyperpolarisedERJ open research · 2022Article
- Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarizedMagnetic resonance in medicine · 2022Article
- Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI.Magnetic resonance in medicine · 2021Article
- Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI.Magnetic resonance in medicine · 2020Article
- Transverse relaxation rates of pulmonary dissolved-phase HyperpolarizedMagnetic resonance in medicine · 2020Article
- QuantitativeScientific reports · 2020Article
- Repeatability of regional pulmonary functional metrics of HyperpolarizedJournal of magnetic resonance imaging : JMRI · 2019Article
- Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With HyperpolarizedIEEE transactions on medical imaging · 2019Article
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14 authors.
Funding
Abstract
purposeTo investigate the feasibility of describing the impact of any flip angle-TR combination on the resulting distribution of the hyperpolarized xenon-129 (HXe) dissolved-phase magnetization in the chest using a single virtual parameter, TR
methodsHXe MRI scans with simultaneous gas- (GP) and dissolved-phase (DP) excitation were performed using 2D projection scans in mechanically ventilated rabbits. Measurements with DP flip angles ranging from 6-90° and TRs ranging from 8.3-500 ms were conducted. DP maps based on acquisitions of similar radio frequency pulse-induced relaxation rates were compared.
resultsThe observed distribution of the DP magnetization was strongly affected by acquisition flip angle and TR. However, for flip angles up to 60°, measurements with the same radio frequency pulse-induced relaxation rates, resulted in very similar DP images despite the presence of significant macroscopic gas transport processes. For flip angles approaching 90°, the downstream signal component decreased noticeably relative to acquisitions with lower flip angles. Nevertheless, the total DP signal continued to follow an empirically verified conversion equation over the entire investigated parameter range, which yields the equivalent TR of a hypothetical 90° measurement for any experimental flip angle-TR combination.
conclusionWe have introduced a method for converting the flip angle and TR of a given HXe DP measurement to a standardized metric based on the virtual quantity, TR
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