ArticleMolecular ecology2019
Altitudinal variation of the gut microbiota in wild house mice.
Article in Molecular ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Gut Microbial Community and Host Thermoregulation in Small Mammals.Frontiers in physiology · 2022Pooled it
- Diversity and compositional changes in the gut microbiota of wild and captive vertebrates: a meta-analysis.Scientific reports · 2021Pooled it
- Study on Gut Microbiota Adaptation of Plateau Zokor (Microorganisms · 2026Article
- Phylosymbiosis and Parallel Geographical Patterns in the Gut Microbiota of Desert-Dwelling Amphibians and Reptiles.Integrative zoology · 2026Article
- Metagenomics reveals gut microbial differences and ecological adaptation in plateau zokor (Eospalax baileyi) populations.BMC microbiology · 2026Article
- Hypobaric hypoxia affects gut microbiota of rats through affected community assembly, reduced network resilience, and metabolic reprogramming.FEMS microbiology ecology · 2026Article
- Sympatric Lepus spp. in the central Italian Alps host significantly different gut microbiotas.Scientific reports · 2026Article
- Short-term high-altitude exposure protects working memory by balancing intestinal microbiota.BMC microbiology · 2026Article
- Gut microbiome plasticity explains the altitudinal distribution pattern and adaptability in a small mammal species (Microbiology spectrum · 2026Article
- Gut bacteriome alterations during high altitude exposure: a comprehensive analysis of different species.Frontiers in microbiology · 2026Review
- Vaginal microecological characterization of women of childbearing age at different altitudes: a multi-omics exploration.BMC women's health · 2025Article
- Moderate altitude exposure impacts extensive host-microbiota multi-kingdom connectivity with serum metabolome and fasting blood glucose.Virulence · 2025Article
- Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia.Scientific reports · 2025Article
- Metabolomic and microbiome integration of Han-Tibetan and plain-plateau populations.BMC biology · 2025Article
- Gut Microbiota and Bacterial Extracellular Vesicles: Emerging Roles in Myocardial Remodelling and Cardiac Health.Journal of extracellular biology · 2025Review
- Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice.AMB Express · 2025Article
- Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods.Microbiology spectrum · 2025Article
- Targeted Screening of Fiber Degrading Bacteria with Probiotic Function in Herbivore Feces.Probiotics and antimicrobial proteins · 2025Article
- Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice.Microbiology spectrum · 2025Article
- Unraveling the pathogenesis and prevention strategies of acute high-altitude illness through gut microecology.NPJ biofilms and microbiomes · 2025Review
15 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The maintenance of oxygen homeostasis in the gut is critical for the maintenance of a healthy gut microbiota. However, few studies have explored how the concentration of atmospheric oxygen affects the gut microbiota in natural populations. High-altitude environments provide an opportunity to study the potential effects of atmospheric oxygen on the composition and function of the gut microbiota. Here, we characterized the caecal microbial communities of wild house mice (Mus musculus domesticus) in two independent altitudinal transects, one in Ecuador and one in Bolivia, from sea level to nearly 4,000 m. First, we found that differences in altitude were associated with differences in the gut microbial community after controlling for the effects of body mass, diet, reproductive status and population of origin. Second, obligate anaerobes tended to show a positive correlation with altitude, while all other microbes tended to show a negative correlation with altitude. These patterns were seen independently in both transects, consistent with the expected effects of atmospheric oxygen on gut microbes. Prevotella was the most-enriched genus at high elevations in both transects, consistent with observations in high-altitude populations of pikas, ruminants and humans, and also consistent with observations of laboratory mice exposed to hypoxic conditions. Lastly, the renin-angiotensin system, a recently proposed microbiota-mediated pathway of blood pressure regulation, was the top predicted metagenomic pathway enriched in high altitudes in both transects. These results suggest that high-altitude environments affect the composition and function of the gut microbiota in wild mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.