Evidence map›Paper›PMID 30346044›Full record

ArticleNeuropathology and applied neurobiology2019

Baseline concentration of misfolded α-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease.

H Ning, Q Wu, D Han, T Yao, J Wang, W Lu, S Lv, Q Jia, X Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology and applied neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

H NingDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Q WuDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
D HanDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
T YaoDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
J WangDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
W LuDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
S LvDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Q JiaDepartment of Digestive Diseases,, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
X LiDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-7499-1420
First Affiliated Hospital of Zhengzhou University · CNSecond Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic significance of misfolded α-synuclein (α-Syn) aggregates in Parkinson's disease (PD) has not been well investigated. The aim of this study was to reveal the relationship between misfolded α-Syn aggregate concentration in cerebrospinal fluid (CSF) and cognitive decline risk in PD.

methodsA total of 278 patients with PD were retrospectively included. They were diagnosed between 2011 and 2013. The end-point was 2016, and the follow-up period was 54.3 ± 10.0 months. Cognitive decline was defined as a 4-point decrease in the Mini-Mental State Examination score during follow-up. Misfolded α-Syn aggregate concentration in baseline CSF was measured using the protein misfolding cyclic amplification (PMCA) technique. Time to reach 50% of the maximum fluorescence value was recorded.

resultsThe PMCA technique successfully detected the level of misfolded α-Syn aggregates in CSF with a sensitivity of 85.3% and a specificity of 91.4%. The time to reach 50% of the maximum fluorescence value was shorter in the patients with cognitive decline than in the patients without cognitive decline (190.7 ± 40.1 h vs. 240.8 ± 45.6 h, P < 0.001). Multifactorial Cox regression analysis revealed that reaching 50% of the maximum fluorescence value in ≤219 h at baseline was associated with increased risk of cognitive decline during the follow-up (HR: 4.90, 95% CI: 2.75-8.74, P < 0.001).

conclusionBaseline concentration of misfolded α-Syn aggregates in CSF measured by the PMCA technique predicts risk of cognitive decline in PD.

Indexed as

AgedAged, 80 and overalpha-SynucleinAmyloid beta-PeptidesBiomarkersCognitive DysfunctionFemaleHumansMaleMiddle AgedParkinson DiseaseRetrospective Studiesalpha-SynucleinAmyloid beta-PeptidesBiomarkersalpha-synucleincognitive declinedementiaParkinson diseaseprotein misfolding cyclic amplification

Identifiers

PMID30346044
PMCPMC7380054
OpenAlexW2897207270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.