ArticleJournal of feline medicine and surgery2019
Profibrotic effects of angiotensin II and transforming growth factor beta on feline kidney epithelial cells.
Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Protective Effects Assessment of Combined Extracts fromVeterinary sciences · 2026Article
- Nephroprotective effect of spexin in dogs and cats.BMC veterinary research · 2026Article
- Unraveling TGF-β1's Role in Mediating Fibrosis and Cell Death in Feline Kidney Cells.Animals : an open access journal from MDPI · 2025Article
- Renal Microcirculation Injury as the Main Cause of Ischemic Acute Kidney Injury Development.Biology · 2023Review
- Alterations of the Gut Microbiota in Patients with Diabetic Nephropathy.Microbiology spectrum · 2022Article
- Hormonal Regulation of Renal Fibrosis.Life (Basel, Switzerland) · 2022Review
- Immunohistochemical Expression of TGF-β1 in Kidneys of Cats with Chronic Kidney Disease.Veterinary sciences · 2022Article
- Protective Effect of Natural Antioxidant Compounds on Methimazole Induced Oxidative Stress in a Feline Kidney Epithelial Cell Line (CRFK).Veterinary sciences · 2021Article
- Inhibition of Crandell-Rees Feline Kidney cell proliferation by X-ray-induced senescence.The Journal of veterinary medical science · 2021Article
- An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update.Frontiers in pharmacology · 2021Review
- Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.Research in veterinary science · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate the role of angiotensin II (AT-II) and its main mediator, transforming growth factor beta 1 (TGF-β1), in the development of feline renal fibrosis.
methodsExpression of marker genes indicating epithelial-to-mesenchymal transition (EMT), profibrotic mediators and matricellular proteins was measured in feline kidney epithelial cells (Crandell Rees feline kidney [CRFK] cells) after incubation with AT-II and/or TGF-β1.
resultsCells incubated with TGF-β1 or the combination of TGF-β1 with AT-II showed clear EMT with more stretched fibroblastic cells, whereas the cells incubated without TGF-β1 and AT-II (control) showed more epithelial cells. Gene expression of collagen type I ( CONCLUSIONS AND RELEVANCE: TGF-β1 significantly induced expression of the EMT marker gene α-SMA, profibrotic mediator
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.