ArticleAdvanced materials (Deerfield Beach, Fla.)2018
Aqueous Two-Phase Emulsion Bioink-Enabled 3D Bioprinting of Porous Hydrogels.
Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Current concepts and new developments of 3D printing in trauma surgery].Der Unfallchirurg · 2019Pooled it
- Advanced cell-instructive bio-inks: Engineering multiscale niches for functional tissue formation.Bioactive materials · 2027Review
- Vat Polymerization 3D Printing of Hydrogels With Tunable Porosity.Small methods · 2026Article
- Aqueous Two-Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells.Advanced healthcare materials · 2026Article
- Article
- In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cell flocculation and phase-separation support macro-scale tissue slab construction in a scaffold-free manner.Materials today. Bio · 2026Article
- Arresting Microphase Separation Encodes Material Mechanics by Sculpting Microarchitectures and Local Polymer Enrichment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Harnessing Phase Separation for the Development of High-Performance Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Microgel-Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-scale Engineered Vasculature and Hierarchical Porosity via Volumetric Bioprinting-Guided Photopolymerization-Induced Phase Separation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration.Journal of Zhejiang University. Science. B · 2025Article
- Hydrogel-based microfluidic model of the blood-brain barrier: progress and future perspectives.Fluids and barriers of the CNS · 2025Review
- 3D endothelial network formation in hydrogels improved by stromal cells and specific growth factors.Scientific reports · 2025Article
- Gelatin Methacrylate Macroporous Cell Scaffold Fabrication via One-Pot Aqueous Two-Phase Separation.Journal of biomedical materials research. Part B, Applied biomaterials · 2025Article
- Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks.Bioactive materials · 2025Article
- Surface-engineered hydrophobic hydrogels via cholesterol micelle rearrangement for robust wet adhesion and oral mucositis therapy.Materials today. Bio · 2025Article
- Tuneable Hydrogel Porosity via Dynamic Tailoring of Spinodal Decomposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rheological, Structural, and Biological Trade-Offs in Bioink Design for 3D Bioprinting.Gels (Basel, Switzerland) · 2025Review
- Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments.Advanced healthcare materials · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
3D bioprinting technology provides programmable and customizable platforms to engineer cell-laden constructs mimicking human tissues for a wide range of biomedical applications. However, the encapsulated cells are often restricted in spreading and proliferation by dense biomaterial networks from gelation of bioinks. Herein, a cell-benign approach is reported to directly bioprint porous-structured hydrogel constructs by using an aqueous two-phase emulsion bioink. The bioink, which contains two immiscible aqueous phases of cell/gelatin methacryloyl (GelMA) mixture and poly(ethylene oxide) (PEO), is photocrosslinked to fabricate predesigned cell-laden hydrogel constructs by extrusion bioprinting or digital micromirror device-based stereolithographic bioprinting. The porous structure of the 3D-bioprinted hydrogel construct is formed by subsequently removing the PEO phase from the photocrosslinked GelMA hydrogel. Three different cell types (human hepatocellular carcinoma cells, human umbilical vein endothelial cells, and NIH/3T3 mouse embryonic fibroblasts) within the 3D-bioprinted porous hydrogel patterns show enhanced cell viability, spreading, and proliferation compared to the standard (i.e., nonporous) hydrogel constructs. The 3D bioprinting strategy is believed to provide a robust and versatile platform to engineer porous-structured tissue constructs and their models for a variety of applications in tissue engineering, regenerative medicine, drug development, and personalized therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.