ArticleCurrent opinion in behavioral sciences2018
Estradiol and hippocampal memory in female and male rodents.
Article in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Effects of estrogen on spatial navigation and memory.Psychopharmacology · 2024Trial
- Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats.Cell reports · 2025Article
- Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice.Frontiers in nutrition · 2025Article
- Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats.Frontiers in behavioral neuroscience · 2025Article
- Beyond Birth Control: The Neuroscience of Hormonal Contraceptives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice.Hormones and behavior · 2024Article
- G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice.Hormones and behavior · 2024Article
- Learning exceptions to category rules varies across the menstrual cycle.Scientific reports · 2023Article
- Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia.Biology of sex differences · 2023Article
- Complexity of Sex Differences and Their Impact on Alzheimer's Disease.Biomedicines · 2023Review
- Effect of estradiol on histopathology of brain in unilateral and bilateral ovariectomized rats.Bioinformation · 2023Article
- Letrozole treatment alters hippocampal gene expression in common marmosets (Callithrix jacchus).Hormones and behavior · 2023Article
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Extracellular matrix metalloproteinase-9 (MMP-9) is required in female mice for 17β-estradiol enhancement of hippocampal memory consolidation.Psychoneuroendocrinology · 2022Article
- Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology.Brain, behavior, & immunity - health · 2022Article
- Individual differences in neurocognitive aging in outbred male and female long-evans rats.Behavioral neuroscience · 2022Article
- Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens.Frontiers in behavioral neuroscience · 2022Article
- Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders.Neural regeneration research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Estrogens influence nearly every aspect of hippocampal function, including memory formation. Although this research has traditionally focused on ovariectomized females, more recent work is providing insights into the ways in which estrogens regulate hippocampal function in both sexes. This review provides an overview of estrogenic regulation of hippocampal function in female and male rodents, with a particular emphasis on memory formation. Where applicable, we discuss the involvement of specific estrogen receptors and molecular mechanisms that mediate these effects. The review concludes by suggesting gaps in the literature that need to be filled to provide greater insights into potential sex differences in the effects of estrogens on hippocampal function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.