Evidence map›Paper›PMID 30345297›Full record

ReviewBioMed research international2018

Psoriasis and Respiratory Comorbidities: The Added Value of Fraction of Exhaled Nitric Oxide as a New Method to Detect, Evaluate, and Monitor Psoriatic Systemic Involvement and Therapeutic Efficacy.

Pierachille Santus, Maurizio Rizzi, Dejan Radovanovic, Andrea Airoldi, Andrea Cristiano, Rosalynn Conic, Stephen Petrou, Paolo Daniele Maria Pigatto, Nicola Bragazzi, Delia Colombo and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Conundrum for Psoriasis and Thyroid Involvement.International journal of molecular sciences · 2023
    Review
  12. Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review.Clinical, cosmetic and investigational dermatology · 2023
    Review
  13. Article
  14. Mapping opportunities for the earlier diagnosis of psoriasis in primary care settings in the UK: results from two matched case-control studies.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
    Article
  15. Article
  16. Article
  17. Exhaled Nitric Oxide Level in Pharynx Angioedema.Journal of clinical medicine · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Pierachille SantusDepartment of Biomedical Sciences L. Sacco, University of Milan, Milan, Italy.
Maurizio RizziRespiratory Unit, Center for Sleep and Respiratory Disorders "Luigi Sacco" University Hospital, Milan, Italy.
Dejan RadovanovicDepartment of Biomedical Sciences L. Sacco, University of Milan, Milan, Italy.
Andrea AiroldiRespiratory Unit, Center for Sleep and Respiratory Disorders "Luigi Sacco" University Hospital, Milan, Italy.
Andrea CristianoRespiratory Unit, Center for Sleep and Respiratory Disorders "Luigi Sacco" University Hospital, Milan, Italy.
Rosalynn ConicDepartment of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
Stephen PetrouDepartment of Emergency Medicine, Good Samaritan Hospital Medical Center, New York, USA.
Paolo Daniele Maria PigattoClinical Dermatology, Department of Biomedical, Surgical and Dental Sciences, IRCCS Galeazzi Orthopaedic Institute, University of Milan, 20126 Milan, Italy.
Nicola BragazziDepartment of Health Sciences (DISSAL), School of Public Health, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-8409-868X
Delia ColomboDepartment of Pharmacology, University of Milan, Milan, Italy.ORCID 0000-0001-6278-3731
Mohamad GoldustMazandaran University of Medical Sciences, Sari, Iran.
Giovanni DamianiDepartment of Dermatology, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-2390-6505
University of Milan · ITLuigi Sacco Hospital · ITCase Western Reserve University · USCentro Studi GISED · ITGood Samaritan University Hospital · USMazandaran University of Medical Sciences · IRUniversity of Genoa · IT

Funding

Psoriasis Center of Research TranslationP50AR070590 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI CAMERON, MARK JAMES · 2017 to 2021
$6.5M
TRAINING IN INVESTIGATIVE AND MOLECULAR DERMATOLOGYT32AR007569 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1991 to 2019
$2.7M
NIAMS NIH HHS P50 AR070590NIAMS NIH HHS T32 AR007569
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory systemic disease characterized by a wide range of comorbidities. Respiratory comorbidities are currently poorly characterized and with discordant results. The systemic state of inflammation caused by psoriasis acts de novo on respiratory tissues and amplifies preexisting inflammation from asthma or chronic obstructive pulmonary disease. Because the lungs act as a gas exchanger between the internal and external environment, the impact of chronic psoriasis inflammation may be easily assessed through the analysis of exhaled breath. The fraction of exhaled nitric oxide test (FeNO) is a potential noninvasive solution that can provide quantitative and qualitative indices of respiratory airway inflammation. FeNO is routinely used to screen and manage asthmatic patients. Recent pilot studies contain encouraging data that underscore its possible use with systemic inflammatory nonpulmonary diseases, such as psoriasis. FeNO may therefore be a useful tool to evaluate underestimated airway inflammation and at the same time globally evaluate the impact of systemically antipsoriatic therapies.

Indexed as

Breath TestsComorbidityHumansInflammationMonitoring, PhysiologicNitric OxidePsoriasisPulmonary Disease, Chronic ObstructiveNitric Oxide

Identifiers

PMID30345297
PMCPMC6174805
OpenAlexW2892749776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.