ArticleVisceral medicine2018
Overstaging: A Challenge in Rectal Cancer Treatment.
Article in Visceral medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Addition of Platinum Derivatives to Fluoropyrimidine-Based Neoadjuvant Chemoradiotherapy for Stage II/III Rectal Cancer: Systematic Review and Meta-Analysis.Journal of the National Cancer Institute · 2019Pooled it
- Urinary metabolomics may improve prediction of overall survival beyond tumor stage in colorectal cancer: results from the ColoCare study.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Pretreatment MRI Versus Postoperative Pathology in Locoregional Staging of Rectal Cancer: A Germany-Wide Multicenter Re-Evaluation Study in Non-Pretreated Patients Based on the OCUM Study.Deutsches Arzteblatt international · 2026Observational
- Short-term outcomes of endoscopic intermuscular dissection for early rectal cancer with deep submucosal infiltration: a single-center experience from China.Techniques in coloproctology · 2025Article
- Intersphincteric abdominoperineal resection with radical en bloc prostatectomy for synchronous or locally advanced rectal or prostate cancer.Surgical endoscopy · 2025Article
- Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter?Cancers · 2024Article
- Intraoperative near infrared functional imaging of rectal cancer using artificial intelligence methods - now and near future state of the art.European journal of nuclear medicine and molecular imaging · 2024Review
- Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel.Abdominal radiology (New York) · 2023Review
- Endoluminal ultrasound versus magnetic resonance imaging in assessment of rectal cancer after neoadjuvant therapy.BMC gastroenterology · 2022Article
- Training of radiology specialists in local staging of primary rectal cancer on MRI: a prospective intervention study exploring the impact of various educational elements on the interpretive performance.BMJ open quality · 2022Article
- Quality of Life after Rectal Cancer Resection Comparing Anterior Resection, Abdominoperineal Resection, and Complicated Cases.Visceral medicine · 2022Article
- Re-evaluation of controversial issues in the treatment of cT3N0-2 rectal cancer: a 10-year cohort analysis using propensity-score matching.International journal of colorectal disease · 2021Article
- Endorectal Ultrasound and Magnetic Resonance Imaging for Rectal Cancer Staging: A Modern Multimodality Approach.Journal of clinical medicine · 2021Article
- How Useful Is Endoscopic Ultrasound in Differentiating T3/T4a T Stage of Colorectal Cancer: A Prospective Study.Frontiers in oncology · 2021Article
- Effect of understaging on local recurrence of rectal cancer.Journal of surgical oncology · 2020Article
- Emerging endoscopic resection strategies for organ preservation in early colorectal cancer.Annals of gastroenterologyReview
- Diffusion-weighted imaging increases the diagnostic performance of magnetic resonance imaging in assessing rectal cancer T stage and reduces intra- and interobserver variability.Annals of gastroenterologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreoperative staging, including computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS), is decisive to envisage the therapeutic concept for rectal cancer (RC). Overstaging may subject the patient to neoadjuvant therapy that does not improve survival but may lead to therapy-associated morbidity.
methodsThis study retrospectively compares and values EUS, CT, and MRI in Union Internationale Contre le Cancer (UICC) stage I-III RC with a focus on overstaging. RC patients receiving primary operation only at the University Clinic Ulm were analyzed. The therapeutic relevance of preoperative staging was determined by comparison with postoperative pathological workup.
results244 examinations in 184 RC patients (EUS: n = 63, CT: n = 143, MRI: n = 38) revealed therapy-relevant overstaging into the T3/4 category in 10 (16%) EUS, 18 (13%) CT, and 10 (26%) MRI cases. Patients were upgraded to the N+ category in 13 (21%) EUS, 29 (20%) CT, and 11 (29%) MRI cases. As a result, UICC stages II and III turned out to be overstaged in 13 (21%) EUS, 18 (13%) CT, and 10 (26%) MRI cases.
conclusionMore than 10% therapy-relevant overstaging by any method represents a major challenge for modern RC therapy. Physicians should scrupulously consider this fact in their treatment considerations to avoid overtreatment.
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