Evidence map›Paper›PMID 30345059›Full record

ArticleJournal of materials chemistry. B2018

Impedance Spectroscopic Detection of Binding and Reactions in Acid-Labile Dielectric Polymers for Biosensor Applications.

Jennifer Dailey, Michelangelo Fichera, Ellen Silbergeld, Howard Katz

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer DaileyDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University.
Michelangelo FicheraDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University.
Ellen SilbergeldDepartment of Environmental Engineering, School of Public Health, Johns Hopkins University.
Howard KatzDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University.

Funding

Transistor and Circuit Designs for Real Time Brain Injury Biomarker DetectionR21EB018426 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, KATZ, HOWARD EDAN · 2015 to 2016
$427k
NIBIB NIH HHS R21 EB018426
6 · The paper itself

Abstract

We synthesized previously unreported copolymers with cleavable acid-labile side chains for use as electrochemical sensing layers in order to demonstrate a novel architecture for a one-step immunosensor. This one-step system is in contrast to most antigen-capture signal amplification methods that involve complicated secondary labeling techniques, or require the addition of redox probes to achieve a sensing response. A series of novel copolymers composed of various trityl-containing monomers were synthesized and characterized to determine their dielectric properties. Results indicate that the thin films of these polymers are stable in water, but some begin to degrade under acidic conditions or upon antigen binding, causing observable changes in the phase angle.

Identifiers

PMID30345059
PMCPMC6191049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.