ReviewF1000Research2018
Recent advances in understanding and managing cholesterol gallstones.
Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Sex and Gender Perspective in Obesity and Gastric Cancer.The world journal of men's health · 2026Review
- The Potential of Microbiota-Modulating Dietary Strategies in Gallstone Prevention: Evidence from 2 Large Population- Based Cohorts.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Association of the Triglyceride-Glucose Index With Gallstone Disease: A Systematic Review and Meta-Analysis of Observational Studies.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- Biliary elimination of cholesterol can be modulated by hepatocyte mitochondrial Aquaporin-8 in mice.Scientific reports · 2026Article
- ULTRASOUND FINDINGS IN THE GALLBLADDER OF ADULT SICKLE CELL ANAEMIA AND SEX-AGE MATCHED NON SICKLE CELL ANAEMIA PATIENTS AT NATIONAL HOSPITAL ABUJA: AN ANALYTIC CROSS SECTIONAL STUDY.Annals of Ibadan postgraduate medicine · 2025Article
- Chest Pain, Family History, and Surgery: A Qualitative Interview Study of Cholecystectomy Patients.The Journal of surgical research · 2025Article
- The mediating role of inflammatory factors in the relationship between obesity and gallstone disease: evidence from the NHANES 2017-2020.European journal of medical research · 2025Article
- True natural orifice transluminal endoscopic surgery-transgastric cholecystectomy and beyond.Clinical endoscopy · 2025Review
- Interplay between lipid profiles, thyroid function, and gallstone disease: A clinical perspective.Journal of family medicine and primary care · 2025Article
- Computer-aided cholelithiasis diagnosis using explainable convolutional neural network.Scientific reports · 2025Article
- The Therapeutic Potential of Low-Intensity Pulsed Ultrasound in Enhancing Gallbladder Function and Reducing Inflammation in Cholesterol Gallstone Disease.Bioengineering (Basel, Switzerland) · 2025Article
- Transformer-powered precision: A DETR-based approach for robust detection in medical ultrasound with cholelithiasis as a case study.Computational and structural biotechnology journal · 2025Article
- Prevalence and Comorbidity Network Analysis of Obesity and Related Complications: A Real-World Study Based on 233,004 Individuals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Modern Management of Common Bile Duct Stones: Breakthroughs, Challenges, and Future Perspectives.Cureus · 2024Review
- Association between sleep and gallstone disease in United States adults: A cross-sectional study.BMC public health · 2024Article
- Cholesterol Gallstones and Long-Term Use of Statins: Is Gut Microbiota Dysbiosis Bridging over Uncertainties?Diagnostics (Basel, Switzerland) · 2024Article
- Different types and numbers metabolic abnormalities and risk of gallbladder stone disease in adults.Frontiers in nutrition · 2024Article
- Comprehensive analysis of differential long non-coding RNA and messenger RNA expression in cholelithiasis using high-throughput sequencing and bioinformatics.Frontiers in genetics · 2024Article
- Nutritional and potential health benefits of chufa oil, olive oil, and anhydrous milk fat against gallstone disease in a C57BL/6N mouse model.Frontiers in nutrition · 2024Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high prevalence of cholesterol gallstones, the availability of new information about pathogenesis, and the relevant health costs due to the management of cholelithiasis in both children and adults contribute to a growing interest in this disease. From an epidemiologic point of view, the risk of gallstones has been associated with higher risk of incident ischemic heart disease, total mortality, and disease-specific mortality (including cancer) independently from the presence of traditional risk factors such as body weight, lifestyle, diabetes, and dyslipidemia. This evidence points to the existence of complex pathogenic pathways linking the occurrence of gallstones to altered systemic homeostasis involving multiple organs and dynamics. In fact, the formation of gallstones is secondary to local factors strictly dependent on the gallbladder (that is, impaired smooth muscle function, wall inflammation, and intraluminal mucin accumulation) and bile (that is, supersaturation in cholesterol and precipitation of solid crystals) but also to "extra-gallbladder" features such as gene polymorphism, epigenetic factors, expression and activity of nuclear receptors, hormonal factors (in particular, insulin resistance), multi-level alterations in cholesterol metabolism, altered intestinal motility, and variations in gut microbiota. Of note, the majority of these factors are potentially manageable. Thus, cholelithiasis appears as the expression of systemic unbalances that, besides the classic therapeutic approaches to patients with clinical evidence of symptomatic disease or complications (surgery and, in a small subgroup of subjects, oral litholysis with bile acids), could be managed with tools oriented to primary prevention (changes in diet and lifestyle and pharmacologic prevention in subgroups at high risk), and there could be relevant implications in reducing both prevalence and health costs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.