ArticlePakistan journal of medical sciences
Role of various complete blood count parameters in predicting the success of single-dose Methotrexate in treating ectopic pregnancy.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Predictive Value of Systemic Inflammatory Markers from Failed Single-Dose Methotrexate Therapy in Tubal Ectopic Pregnancy: A Retrospective Single-Center Study.Journal of inflammation research · 2026Article
- Hormonal and electrolyte predictors for methotrexate versus surgery in ectopic pregnancy.PloS one · 2025Article
- Can failure be predicted in methotrexate treatment with the modified parameter?Archives of gynecology and obstetrics · 2024Article
- Prediction of Tubal Rupture in Ectopic Pregnancy Using Methotrexate Treatment Protocols and Hematological Markers.Journal of clinical medicine · 2023Article
- The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies.Turkish journal of obstetrics and gynecology · 2023Article
- Prediction of Rupture by Complete Blood Count in Tubal Ectopic Pregnancies Treated with a Single-Dose Methotrexate Protocol.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Association Between White Blood Cells at Baseline and Treatment Failure of MTX for Ectopic Pregnancy.Frontiers in medicine · 2021Article
- Overview of ectopic pregnancy diagnosis, management, and innovation.Women's health (London, England)Review
- Treatment success with two doses of methotrexate vs single dose of methotrexate in Ectopic Tubal Pregnancy.Pakistan journal of medical sciencesArticle
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4 authors.
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Abstract
objectiveThe protocol of 15% BhCG decrease between Days four and seven is frequently used for evaluating the success of methotrexate administration in treating ectopic pregnancy. Our objective was to study the usage of hematologic parameters for evaluating the success of methotrexate administration in treating ectopic pregnancy.
methodThis study was conducted between February 2014 and December 2016. Data of 434 patients were retrospectively scanned for the study. One hundred sixty-one patients whose Day one, four and seven results were recorded in the hospital information system and who were followed up until their BhCG levels decreased <10 IU/L were enrolled in the study. Three types of complete blood cell count parameters of the patients were used: 1) Neutrophil-to-lymphocyte ratio (NLR). 2) Platelet distribution width (PDW), 3) Platelet count (PLT).
resultsPatients were separated into two groups as those who were treated with single-dose methotrexate and those who required surgical treatment. A significant difference was detected between the groups in terms of NLR levels on Days 1, 4, and 7 (p=0.012, p=0.035, and p=0.001, respectively). There was no significant difference detected between the groups for PDW and PLT counts on Days one, four and seven.
conclusionsNLR can also be used as an alternative to BhCG for evaluating the success of single-dose methotrexate administration in treating ectopic pregnancy. However, there is need for further studies on this topic.
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