ArticleFrontiers in molecular neuroscience2018
Bridging Synaptic and Epigenetic Maintenance Mechanisms of the Engram.
Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.Psychopharmacology · 2026Article
- On the molecular basis of enduring memory in neurons, and cell fate in fibroblasts.Nucleic acids research · 2026Review
- Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons.bioRxiv : the preprint server for biology · 2025Article
- Learning induces persistent chromatin loops underlying robust gene expression during memory recall.bioRxiv : the preprint server for biology · 2025Article
- Epigenetics of Chronic Stress: Mechanisms and Health Impacts.Current genomics · 2025Review
- Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation.Communications biology · 2024Article
- Review
- Unveiling Transcriptional and Epigenetic Mechanisms Within Engram Cells: Insights into Memory Formation and Stability.Advances in neurobiology · 2024Review
- Tissue clearing applications in memory engram research.Frontiers in behavioral neuroscience · 2023Review
- A New Concept of Associations between Gut Microbiota, Immunity and Central Nervous System for the Innovative Treatment of Neurodegenerative Disorders.Metabolites · 2022Article
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
- Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction.Molecular psychiatry · 2022Review
- The Immediate Early Gene Arc Is Not Required for Hippocampal Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- A Synaptic Framework for the Persistence of Memory Engrams.Frontiers in synaptic neuroscience · 2021Review
- mRNA and microRNA Profiles in the Amygdala Are Relevant to Susceptibility and Resilience to Psychological Stress Induced in Mice.Journal of molecular neuroscience : MN · 2020Article
- NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms.Schizophrenia research · 2020Review
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience.Frontiers in molecular neuroscience · 2020Review
- Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.Neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How memories are maintained, and how memories are lost during aging or disease, are intensely investigated issues. Arguably, the reigning theory is that synaptic modifications allow for the formation of engrams during learning, and sustaining engrams sustains memory. Activity-regulated gene expression profiles have been shown to be critical to these processes, and their control by the epigenome has begun to be investigated in earnest. Here, we propose a novel theory as to how engrams are sustained. We propose that many of the genes that are currently believed to underlie long-term memory are actually part of a "plasticity transcriptome" that underpins structural and functional modifications to neuronal connectivity during the hours to days following learning. Further, we hypothesize that a "maintenance transcriptome" is subsequently induced that includes epigenetic negative regulators of gene expression, particularly histone deacetylases. The maintenance transcriptome negatively regulates the plasticity transcriptome, and thus the plastic capability of a neuron, after learning. In this way, the maintenance transcriptome would act as a metaplasticity mechanism that raises the threshold for change in neurons within an engram, helping to ensure the connectivity is stabilized and memory is maintained.
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