Observational studyWorld journal of gastroenterology2018
Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia.
Observational study in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Ultrasound-derived fat fraction and automated point shear-wave elastography in diagnosing intrahepatic cholestasis of pregnancy and preeclampsia.BMC pregnancy and childbirth · 2026Article
- Evaluating metabolic dysfunction-associated steatotic liver disease, associated adverse pregnancy outcomes, and postpartum maternal course utilising transient elastography with controlled attenuation parameter in pregnancy: a prospective cohort study.The Lancet. Obstetrics, gynaecology, & women's health · 2026Article
- Metabolic dysfunction-associated steatotic liver disease and pregnancy.The Journal of clinical investigation · 2025Review
- Article
- Diagnostic Approach to Elevated Liver Function Tests during Pregnancy: A Pragmatic Narrative Review.Journal of personalized medicine · 2023Article
- Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study.World journal of hepatology · 2023Article
- Screening for maternal cytomegalovirus infection during pregnancy and pregnancy outcome in patients with liver disease: an observational study.BMC infectious diseases · 2023Observational
- Imaging of pregnancy-related liver diseases.iLIVER · 2023Review
- Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease.Journal of clinical medicine · 2023Article
- Metabolic associated fatty liver disease and adverse maternal and fetal outcomes: a systematic review and meta-analysis.Clinical and experimental hepatology · 2021Article
- Liver Disease in Pregnancy: What's New.Hepatology communications · 2020Article
- Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy.Frontiers in physiology · 2020Article
- Noninvasive Tests for Prognosticating Outcomes in Patients With Chronic Liver Disease in Pregnancy: Ready for Prime Time?The American journal of gastroenterology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study liver stiffness (LS) during pregnancy and its association with complications during pregnancy.
methodsIn this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device (Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women (controls) while preeclampsia and intrahepatic cholestasis of pregnancy (ICP) developed in 22 and 40 women, respectively.
resultsIn controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa (
conclusionDuring pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent non-invasive predictor.
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