Evidence map›Paper›PMID 30344363›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2015

Tract specific analysis in patients with sickle cell disease.

Yaqiong Chai, Julie Coloigner, Xiaoping Qu, Soyoung Choi, Adam Bush, Matt Borzage, Chau Vu, Natasha Lepore, John Wood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaqiong ChaiCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Julie ColoignerCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Xiaoping QuCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Soyoung ChoiDivision of Cardiology, Children's Hospital Los Angeles, CA, USA.
Adam BushDivision of Cardiology, Children's Hospital Los Angeles, CA, USA.
Matt BorzageDepartment of Neonatology, Children's Hospital Los Angeles, CA, USA.
Chau VuDivision of Cardiology, Children's Hospital Los Angeles, CA, USA.
Natasha LeporeCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
John WoodDivision of Cardiology, Children's Hospital Los Angeles, CA, USA.

Funding

Neuromodulatory Mechanisms and Regional Autonomic Dysregulation in the Development of Pain in Sickle Cell Disease PatientsU01HL117718 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COATES, THOMAS DUANE, KHOO, MICHAEL C K · 2013 to 2017
$9.6M
Statistical Methods for Brain Image Registration and Tensor-Based MorphometryR21EB012177 · NIBIB · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA · 2011 to 2012
$478k
NHLBI NIH HHS U01 HL117718NIBIB NIH HHS R21 EB012177
6 · The paper itself

Abstract

Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. It affects numerous people in the world and leads to a shorter life span, pain, anemia, serious infections and neurocognitive decline. Tract-Specific Analysis (TSA) is a statistical method to evaluate white matter alterations due to neurocognitive diseases, using diffusion tensor magnetic resonance images. Here, for the first time, TSA is used to compare 11 major brain white matter (WM) tracts between SCD patients and age-matched healthy subjects. Alterations are found in the corpus callosum (CC), the cortico-spinal tract (CST), inferior fronto-occipital fasciculus (IFO), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and uncinated fasciculus (UNC). Based on previous studies on the neurocognitive functions of these tracts, the significant areas found in this paper might be related to several cognitive impairments and depression, both of which are observed in SCD patients.

Indexed as

sickle cell diseasestatistical analysiswhite matter

Identifiers

PMID30344363
PMCPMC6192019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.