Evidence map›Paper›PMID 30344353›Full record

ArticleTetrahedron letters2018

Lipidated cyclopropenes

Pratik Kumar, Ting Jiang, Omar Zainul, Alyssa N Preston, Sining Li, Joshua D Farr, Pavit Suri, Scott T Laughlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pratik KumarDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Ting JiangDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Omar ZainulDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Alyssa N PrestonDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Sining LiDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Joshua D FarrDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Pavit SuriDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.
Scott T LaughlinDepartment of Chemistry, Stony Brook University, Stony Brook, NY, 11790, United States.

Funding

SBU Chemistry-Biology Interface Training ProgramT32GM092714 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S, TONGE, PETER J · 2010 to 2019
$1.7M
NIGMS NIH HHS T32 GM092714
6 · The paper itself

Abstract

Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene's small size and ability to ligate with pro-fluorescent tetrazines. Previously, the lipidation of cyclopropenes required modification at the C3 position because methods to append lipids at C1/C2 were not available. Herein, we describe C1/C2 lipidation with the biologically active lipid ceramide and a common phospholipid using a cyclopropene scaffold whose reactivity with 1,2,4,5-tetrazines has been caged.

Indexed as

Bioorthogonal chemistryClick chemistryCyclopropene tetrazineLipidphotocage

Identifiers

PMID30344353
PMCPMC6190722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.