Evidence map›Paper›PMID 30344284›Full record

ReviewMedicina (Kaunas, Lithuania)2018

Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle.

Ieva Antanavičiūtė, Paulius Gibieža, Rytis Prekeris, Vytenis Arvydas Skeberdis

Open access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Condensates on the Move: Midbody Remnants as Large, Translation-Competent Extracellular Vesicles.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. They Might Cut It-Lysosomes and Autophagy in Mitotic Progression.Frontiers in cell and developmental biology · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ieva AntanavičiūtėInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania. Ieva.Antanaviciute@lsmuni.lt.ORCID 0000-0002-7406-0298
Paulius GibiežaInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania. Paulius.Gibieza@lsmuni.lt.
Rytis PrekerisDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Rytis.Prekeris@ucdenver.edu.
Vytenis Arvydas SkeberdisInstitute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania. Arvydas.Skeberdis@lsmuni.lt.
Lithuanian University of Health Sciences · LTUniversity of Colorado Anschutz Medical Campus · US

Funding

Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and CiliogenesisR01DK064380 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Rytis Prekeris · 2004 to 2026
$7.1M
The mechanisms regulating actin dynamics and polarized membrane transport during invadopodia formationR01GM122768 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PREKERIS, RYTIS · 2018 to 2025
$2.6M
Lietuvos Mokslo Taryba APP-7/2016National Institutes of Health R01-DK064380National Institutes of Health R01-GM122768NIDDK NIH HHS R01 DK064380NIGMS NIH HHS R01 GM122768
6 · The paper itself

Abstract

Faithful cell division is crucial for successful proliferation, differentiation, and development of cells, tissue homeostasis, and preservation of genomic integrity. Cytokinesis is a terminal stage of cell division, leaving two genetically identical daughter cells connected by an intercellular bridge (ICB) containing the midbody (MB), a large protein-rich organelle, in the middle. Cell division may result in asymmetric or symmetric abscission of the ICB. In the first case, the ICB is severed on the one side of the MB, and the MB is inherited by the opposite daughter cell. In the second case, the MB is cut from both sides, expelled into the extracellular space, and later it can be engulfed by surrounding cells. Cells with lower autophagic activity, such as stem cells and cancer stem cells, are inclined to accumulate MBs. Inherited MBs affect cell polarity, modulate intra- and intercellular communication, enhance pluripotency of stem cells, and increase tumorigenic potential of cancer cells. In this review, we briefly summarize the latest knowledge on MB formation, inheritance, degradation, and function, and in addition, present and discuss our recent findings on the electrical and chemical communication of cells connected through the MB-containing ICB.

Indexed as

Cell DifferentiationCytokinesisHumansMitosisOrganellesSignal Transductionconductancecytokinesisintercellular bridgemidbodypermeabilitytumorigenicity

Identifiers

PMID30344284
PMCPMC6174351
OpenAlexW2519829189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.